EC: 2.3.2.24

(E3-independent) E2 ubiquitin-conjugating enzyme (S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:L-lysine ubiquitinyl transferase ([E3 ubiquitin transferase]-independent))

enzyme lambda metabolic reaction experiment

Pathways

pathway id name
Reactome:R-HSA-8853884 Transcriptional Regulation by VENTX
Reactome:R-HSA-9700206 Signaling by ALK in cancer
Reactome:R-HSA-9824439 Bacterial Infection Pathways
Reactome:R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects
Reactome:R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects
Reactome:R-HSA-9725370 Signaling by ALK fusions and activated point mutants
Reactome:R-HSA-9675126 Diseases of mitotic cell cycle
Reactome:R-HSA-9932298 Degradation of CRY and PER proteins
Reactome:R-MMU-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Reactome:R-RNO-9948299 Ribosome-associated quality control
Reactome:R-HSA-9640148 Infection with Enterobacteria
Reactome:R-RNO-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Reactome:R-HSA-9909396 Circadian clock
Reactome:R-BTA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Reactome:R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Reactome:R-MMU-9948299 Ribosome-associated quality control
Reactome:R-BTA-9948299 Ribosome-associated quality control
Reactome:R-HSA-9948299 Ribosome-associated quality control
Reactome:R-HSA-9956593 Enterobacterial factors antagonize host defense
Reactome:R-DME-174154 APC/C:Cdc20 mediated degradation of Securin
Reactome:R-BTA-1640170 Cell Cycle
Reactome:R-BTA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Reactome:R-BTA-69239 Synthesis of DNA
Reactome:R-BTA-69017 CDK-mediated phosphorylation and removal of Cdc6
Reactome:R-BTA-174143 APC/C-mediated degradation of cell cycle proteins
Reactome:R-BTA-176412 Phosphorylation of the APC/C
Reactome:R-BTA-179409 APC-Cdc20 mediated degradation of Nek2A
Reactome:R-BTA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Reactome:R-BTA-8953897 Cellular responses to stimuli
Reactome:R-BTA-2262752 Cellular responses to stress
Reactome:R-BTA-2559583 Cellular Senescence
Reactome:R-BTA-68867 Assembly of the pre-replicative complex
Reactome:R-DME-69239 Synthesis of DNA
Reactome:R-DME-69017 CDK-mediated phosphorylation and removal of Cdc6
Reactome:R-DME-2559583 Cellular Senescence
Reactome:R-DME-2559582 Senescence-Associated Secretory Phenotype (SASP)
Reactome:R-DME-69278 Cell Cycle, Mitotic
Reactome:R-DME-453276 Regulation of mitotic cell cycle
Reactome:R-DME-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome:R-DME-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Reactome:R-DME-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Reactome:R-HSA-75893 TNF signaling
Reactome:R-HSA-5357905 Regulation of TNFR1 signaling
Reactome:R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
Reactome:R-HSA-69620 Cell Cycle Checkpoints
Reactome:R-HSA-69618 Mitotic Spindle Checkpoint
Reactome:R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
Reactome:R-HSA-69239 Synthesis of DNA
Reactome:R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
Reactome:R-HSA-2555396 Mitotic Metaphase and Anaphase
Reactome:R-HSA-453276 Regulation of mitotic cell cycle
Reactome:R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Reactome:R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
Reactome:R-HSA-392499 Metabolism of proteins
Reactome:R-HSA-1643685 Disease
Reactome:R-HSA-69002 DNA Replication Pre-Initiation
Reactome:R-HSA-74160 Gene expression (Transcription)
Reactome:R-HSA-73857 RNA Polymerase II Transcription
Reactome:R-MMU-1640170 Cell Cycle
Reactome:R-MMU-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Reactome:R-MMU-69239 Synthesis of DNA
Reactome:R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6
Reactome:R-MMU-68882 Mitotic Anaphase
Reactome:R-MMU-176408 Regulation of APC/C activators between G1/S and early anaphase
Reactome:R-MMU-176412 Phosphorylation of the APC/C
Reactome:R-MMU-179409 APC-Cdc20 mediated degradation of Nek2A
Reactome:R-MMU-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Reactome:R-MMU-68867 Assembly of the pre-replicative complex
Reactome:R-MMU-162582 Signaling Pathways
Reactome:R-RNO-69620 Cell Cycle Checkpoints
Reactome:R-RNO-69618 Mitotic Spindle Checkpoint
Reactome:R-RNO-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
Reactome:R-RNO-68886 M Phase
Reactome:R-RNO-2467813 Separation of Sister Chromatids
Reactome:R-RNO-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome:R-RNO-174048 APC/C:Cdc20 mediated degradation of Cyclin B
Reactome:R-RNO-174084 Autodegradation of Cdh1 by Cdh1:APC/C
Reactome:R-RNO-72766 Translation
Reactome:R-RNO-69002 DNA Replication Pre-Initiation
Reactome:R-RNO-2559582 Senescence-Associated Secretory Phenotype (SASP)
Reactome:R-RNO-162582 Signaling Pathways
Reactome:R-RNO-73887 Death Receptor Signaling
Reactome:R-BTA-2555396 Mitotic Metaphase and Anaphase
Reactome:R-BTA-453276 Regulation of mitotic cell cycle
Reactome:R-BTA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome:R-BTA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Reactome:R-BTA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Reactome:R-BTA-69002 DNA Replication Pre-Initiation
Reactome:R-BTA-162582 Signaling Pathways
Reactome:R-BTA-75893 TNF signaling
Reactome:R-BTA-5357905 Regulation of TNFR1 signaling
Reactome:R-DME-68867 Assembly of the pre-replicative complex
Reactome:R-DME-8953897 Cellular responses to stimuli
Reactome:R-DME-69620 Cell Cycle Checkpoints
Reactome:R-DME-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
Reactome:R-DME-69242 S Phase
Reactome:R-DME-68886 M Phase
Reactome:R-DME-2467813 Separation of Sister Chromatids
Reactome:R-DME-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Reactome:R-DME-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Reactome:R-HSA-2262752 Cellular responses to stress
Reactome:R-HSA-2559583 Cellular Senescence
Reactome:R-HSA-1640170 Cell Cycle
Reactome:R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Reactome:R-HSA-2467813 Separation of Sister Chromatids
Reactome:R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome:R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B
Reactome:R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C
Reactome:R-HSA-69306 DNA Replication
Reactome:R-MMU-174143 APC/C-mediated degradation of cell cycle proteins
Reactome:R-MMU-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome:R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Reactome:R-MMU-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Reactome:R-MMU-69002 DNA Replication Pre-Initiation
Reactome:R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
Reactome:R-MMU-75893 TNF signaling
Reactome:R-MMU-5357905 Regulation of TNFR1 signaling
Reactome:R-RNO-1640170 Cell Cycle
Reactome:R-RNO-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Reactome:R-RNO-69239 Synthesis of DNA
Reactome:R-RNO-69017 CDK-mediated phosphorylation and removal of Cdc6
Reactome:R-RNO-68882 Mitotic Anaphase
Reactome:R-RNO-176408 Regulation of APC/C activators between G1/S and early anaphase
Reactome:R-RNO-176412 Phosphorylation of the APC/C
Reactome:R-RNO-179409 APC-Cdc20 mediated degradation of Nek2A
Reactome:R-RNO-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Reactome:R-RNO-392499 Metabolism of proteins
Reactome:R-RNO-69306 DNA Replication
Reactome:R-RNO-8953897 Cellular responses to stimuli
Reactome:R-RNO-2262752 Cellular responses to stress
Reactome:R-RNO-2559583 Cellular Senescence
Reactome:R-BTA-392499 Metabolism of proteins
Reactome:R-BTA-69620 Cell Cycle Checkpoints
Reactome:R-BTA-69618 Mitotic Spindle Checkpoint
Reactome:R-BTA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
Reactome:R-BTA-68886 M Phase
Reactome:R-BTA-68882 Mitotic Anaphase
Reactome:R-BTA-176408 Regulation of APC/C activators between G1/S and early anaphase
Reactome:R-BTA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome:R-BTA-174048 APC/C:Cdc20 mediated degradation of Cyclin B
Reactome:R-BTA-174084 Autodegradation of Cdh1 by Cdh1:APC/C
Reactome:R-BTA-2559582 Senescence-Associated Secretory Phenotype (SASP)
Reactome:R-BTA-73887 Death Receptor Signaling
Reactome:R-DME-69306 DNA Replication
Reactome:R-DME-2262752 Cellular responses to stress
Reactome:R-DME-69618 Mitotic Spindle Checkpoint
Reactome:R-DME-2555396 Mitotic Metaphase and Anaphase
Reactome:R-DME-174143 APC/C-mediated degradation of cell cycle proteins
Reactome:R-DME-176412 Phosphorylation of the APC/C
Reactome:R-DME-179409 APC-Cdc20 mediated degradation of Nek2A
Reactome:R-DME-174084 Autodegradation of Cdh1 by Cdh1:APC/C
Reactome:R-HSA-69278 Cell Cycle, Mitotic
Reactome:R-HSA-174143 APC/C-mediated degradation of cell cycle proteins
Reactome:R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome:R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Reactome:R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Reactome:R-HSA-72766 Translation
Reactome:R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
Reactome:R-HSA-68867 Assembly of the pre-replicative complex
Reactome:R-HSA-212436 Generic Transcription Pathway
Reactome:R-MMU-69620 Cell Cycle Checkpoints
Reactome:R-MMU-69618 Mitotic Spindle Checkpoint
Reactome:R-MMU-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
Reactome:R-MMU-68886 M Phase
Reactome:R-MMU-2467813 Separation of Sister Chromatids
Reactome:R-MMU-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome:R-MMU-174048 APC/C:Cdc20 mediated degradation of Cyclin B
Reactome:R-MMU-174084 Autodegradation of Cdh1 by Cdh1:APC/C
Reactome:R-MMU-73887 Death Receptor Signaling
Reactome:R-MMU-392499 Metabolism of proteins
Reactome:R-RNO-69278 Cell Cycle, Mitotic
Reactome:R-RNO-69242 S Phase
Reactome:R-RNO-69052 Switching of origins to a post-replicative state
Reactome:R-RNO-2555396 Mitotic Metaphase and Anaphase
Reactome:R-RNO-453276 Regulation of mitotic cell cycle
Reactome:R-RNO-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Reactome:R-RNO-174154 APC/C:Cdc20 mediated degradation of Securin
Reactome:R-RNO-68867 Assembly of the pre-replicative complex
Reactome:R-BTA-72766 Translation
Reactome:R-BTA-69278 Cell Cycle, Mitotic
Reactome:R-BTA-69242 S Phase
Reactome:R-BTA-69052 Switching of origins to a post-replicative state
Reactome:R-BTA-2467813 Separation of Sister Chromatids
Reactome:R-BTA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Reactome:R-BTA-174154 APC/C:Cdc20 mediated degradation of Securin
Reactome:R-BTA-69306 DNA Replication
Reactome:R-DME-69002 DNA Replication Pre-Initiation
Reactome:R-DME-69052 Switching of origins to a post-replicative state
Reactome:R-DME-1640170 Cell Cycle
Reactome:R-DME-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Reactome:R-DME-68882 Mitotic Anaphase
Reactome:R-DME-176408 Regulation of APC/C activators between G1/S and early anaphase
Reactome:R-DME-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome:R-DME-174048 APC/C:Cdc20 mediated degradation of Cyclin B
Reactome:R-HSA-162582 Signaling Pathways
Reactome:R-HSA-73887 Death Receptor Signaling
Reactome:R-HSA-8953897 Cellular responses to stimuli
Reactome:R-HSA-69242 S Phase
Reactome:R-HSA-69052 Switching of origins to a post-replicative state
Reactome:R-HSA-68886 M Phase
Reactome:R-HSA-68882 Mitotic Anaphase
Reactome:R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
Reactome:R-HSA-176412 Phosphorylation of the APC/C
Reactome:R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A
Reactome:R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Reactome:R-HSA-5663205 Infectious disease
Reactome:R-MMU-69278 Cell Cycle, Mitotic
Reactome:R-MMU-69242 S Phase
Reactome:R-MMU-69052 Switching of origins to a post-replicative state
Reactome:R-MMU-2555396 Mitotic Metaphase and Anaphase
Reactome:R-MMU-453276 Regulation of mitotic cell cycle
Reactome:R-MMU-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Reactome:R-MMU-174154 APC/C:Cdc20 mediated degradation of Securin
Reactome:R-MMU-69306 DNA Replication
Reactome:R-MMU-8953897 Cellular responses to stimuli
Reactome:R-MMU-2262752 Cellular responses to stress
Reactome:R-MMU-2559583 Cellular Senescence
Reactome:R-MMU-72766 Translation
Reactome:R-RNO-174143 APC/C-mediated degradation of cell cycle proteins
Reactome:R-RNO-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome:R-RNO-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Reactome:R-RNO-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Reactome:R-RNO-75893 TNF signaling
Reactome:R-RNO-5357905 Regulation of TNFR1 signaling
WikiPathways:WP4016 DNA IR-damage and cellular response via ATR
PathBank:SMP0120905 Ubiquitin Proteasome Pathway
PathBank:SMP0120953 Ubiquitin Proteasome Pathway
PathBank:SMP0063816 Ubiquitin Proteasome Pathway