EC: 2.3.1.48

histone acetyltransferase (acetyl-CoA:[protein]-L-lysine acetyltransferase)

enzyme lambda metabolic reaction experiment
uniprot:Q03330 [histone acetyltransferase(Enzyme) wildtype]

Acetyl_CoA + Histone -> Coenzyme_A + Acetylhistone
(( (( (( (E * kcat) ) * A) ) * B) ) / (( (( (( (Kia * Kmb) ) + (Kma * B)) ) + (Kmb * A)) ) + (A * B))) buffer: 100 mM Sodium acetate, 50 mM Bis-Tris, 50 mM Tris, 0.2 mM NAD, 0.2 mM Thiamine pyrophosphat, 5 mM MgCl2, 1 mM Dithiothreitol, 2.4 mM Pyruvate, 0.03 units Pyruvate dehydrogenase, 0.2 mM NAD, 0.2 mM Thiamine pyrophosphat, 5 mM MgCl2, 1 mM Dithiothreitol, 2.4 mM Pyruvate, 0.03 units Pyruvate dehydrogenase
PH: 7.5
Temperature: 25
uniprot:Q03330 [desulfo-CoA]

Histone + Acetyl_CoA -> Acetylhistone + Coenzyme_A
(( (( (E * kcat) ) * S) ) / (( (Km * (1 + (I / Kis))) ) + S)) buffer: 100 mM Sodium acetate, 50 mM Bis-Tris, 50 mM Tris, 0.2 mM NAD, 0.2 mM Thiamine pyrophosphat, 5 mM MgCl2, 1 mM Dithiothreitol, 2.4 mM Pyruvate, 0.03 units Pyruvate dehydrogenase
PH: 7.5
Temperature: 25
uniprot:Q03330 [histone acetyltransferase(Enzyme) wildtype]

Histone + Acetyl_CoA -> Coenzyme_A + Acetylhistone
(( (( (E * kcat) ) * S) ) / (( (Km * (1 + (I / Kis))) ) + (S * (1 + (I / Kii))))) buffer: 100 mM Sodium acetate, 50 mM Bis-Tris, 50 mM Tris, 0.2 mM NAD, 0.2 mM Thiamine pyrophosphat, 5 mM MgCl2, 1 mM Dithiothreitol, 2.4 mM Pyruvate, 0.03 units Pyruvate dehydrogenase
PH: 7.5
Temperature: 25
uniprot:Q03330 [histone acetyltransferase(Enzyme) wildtype]

Acetyl_CoA + Histone -> Coenzyme_A + Acetylhistone
(( (( (E * kcat) ) * S) ) / (( (Km * (1 + (I / Kis))) ) + (S * (1 + (I / Kii))))) buffer: 100 mM Sodium acetate, 50 mM Bis-Tris, 50 mM Tris, 0.2 mM NAD, 0.2 mM Thiamine pyrophosphat, 5 mM MgCl2, 1 mM Dithiothreitol, 2.4 mM Pyruvate, 0.03 units Pyruvate dehydrogenase
PH: 7.5
Temperature: 25
uniprot:Q03330 [histone acetyltransferase(Enzyme) wildtype]

Acetyl_CoA + Histone -> Coenzyme_A + Acetylhistone
(( (( (E * kcat) ) * S) ) / (( (Km * (1 + (I / Kis))) ) + S)) buffer: 100 mM Sodium acetate, 50 mM Bis-Tris, 50 mM Tris, 0.2 mM NAD, 0.2 mM Thiamine pyrophosphat, 5 mM MgCl2, 1 mM Dithiothreitol, 2.4 mM Pyruvate, 0.03 units Pyruvate dehydrogenase
PH: 7.5
Temperature: 25

Pathways

pathway id name
BioCyc:ARA_PWY-6922 L-Nδ-acetylornithine biosynthesis
PlantCyc:ARA_PWY-6922 L-Nδ-acetylornithine biosynthesis
Reactome:R-MMU-9623433 LXRs regulate gene expression to control bile acid homeostasis
Reactome:R-MMU-9029569 LXRs regulate gene expression linked to cholesterol transport and efflux
Reactome:R-MMU-9024446 LXR-mediated signaling
Reactome:R-HSA-9616222 Transcriptional regulation of granulopoiesis
Reactome:R-HSA-9029569 LXRs regulate gene expression linked to cholesterol transport and efflux
Reactome:R-HSA-9623433 LXRs regulate gene expression to control bile acid homeostasis
Reactome:R-HSA-9024446 LXR-mediated signaling
Reactome:R-HSA-9679506 SARS-CoV Infections
Reactome:R-HSA-9694516 SARS-CoV-2 Infection
Reactome:R-MMU-201556 Signaling by ALK
Reactome:R-CEL-9759194 Nuclear events mediated by NFE2L2
Reactome:R-HSA-9758941 Gastrulation
Reactome:R-HSA-9692914 SARS-CoV-1-host interactions
Reactome:R-RNO-9772755 Formation of WDR5-containing histone-modifying complexes
Reactome:R-DME-9772755 Formation of WDR5-containing histone-modifying complexes
Reactome:R-HSA-9843745 Adipogenesis
Reactome:R-MMU-9856649 Transcriptional and post-translational regulation of MITF-M expression and activity
Reactome:R-RNO-9856649 Transcriptional and post-translational regulation of MITF-M expression and activity
Reactome:R-CEL-9701898 STAT3 nuclear events downstream of ALK signaling
Reactome:R-CEL-9755511 KEAP1-NFE2L2 pathway
Reactome:R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses
Reactome:R-HSA-9793380 Formation of paraxial mesoderm
Reactome:R-MMU-9772755 Formation of WDR5-containing histone-modifying complexes
Reactome:R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes
Reactome:R-HSA-9733709 Cardiogenesis
Reactome:R-HSA-9833109 Evasion by RSV of host interferon responses
Reactome:R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activity
Reactome:R-MMU-9730414 MITF-M-regulated melanocyte development
Reactome:R-RNO-9730414 MITF-M-regulated melanocyte development
Reactome:R-HSA-9678108 SARS-CoV-1 Infection
Reactome:R-CEL-9711123 Cellular response to chemical stress
Reactome:R-HSA-9707616 Heme signaling
Reactome:R-MMU-9701898 STAT3 nuclear events downstream of ALK signaling
Reactome:R-HSA-201556 Signaling by ALK
Reactome:R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways
Reactome:R-HSA-9634815 Transcriptional Regulation by NPAS4
Reactome:R-HSA-9768919 NPAS4 regulates expression of target genes
Reactome:R-HSA-9824446 Viral Infection Pathways
Reactome:R-HSA-9816359 Maternal to zygotic transition (MZT)
Reactome:R-HSA-9819196 Zygotic genome activation (ZGA)
Reactome:R-CEL-9730414 MITF-M-regulated melanocyte development
Reactome:R-HSA-9031628 NGF-stimulated transcription
Reactome:R-CEL-201556 Signaling by ALK
Reactome:R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling
Reactome:R-HSA-9705683 SARS-CoV-2-host interactions
Reactome:R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway
Reactome:R-HSA-9833110 RSV-host interactions
Reactome:R-CEL-9856649 Transcriptional and post-translational regulation of MITF-M expression and activity
Reactome:R-HSA-9730414 MITF-M-regulated melanocyte development
Reactome:R-DME-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes
Reactome:R-MMU-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes
Reactome:R-RNO-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes
Reactome:R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
Reactome:R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes
Reactome:R-HSA-9931529 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK
Reactome:R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
Reactome:R-HSA-9839373 Signaling by TGFBR3
Reactome:R-HSA-9909396 Circadian clock
Reactome:R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters
Reactome:R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Reactome:R-HSA-9839394 TGFBR3 expression
Reactome:R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2
Reactome:R-CEL-201722 Formation of the beta-catenin:TCF transactivating complex
Reactome:R-CEL-9614085 FOXO-mediated transcription
Reactome:R-DRE-9614085 FOXO-mediated transcription
Reactome:R-HSA-9614085 FOXO-mediated transcription
Reactome:R-CEL-8951936 RUNX3 regulates p14-ARF
Reactome:R-RNO-9617629 Regulation of FOXO transcriptional activity by acetylation
Reactome:R-MMU-9614085 FOXO-mediated transcription
Reactome:R-CEL-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
Reactome:R-CEL-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Reactome:R-RNO-9614085 FOXO-mediated transcription
Reactome:R-MMU-9617629 Regulation of FOXO transcriptional activity by acetylation
Reactome:R-CEL-9617629 Regulation of FOXO transcriptional activity by acetylation
Reactome:R-DRE-9617629 Regulation of FOXO transcriptional activity by acetylation
Reactome:R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation
Reactome:R-CEL-2990846 SUMOylation
Reactome:R-CEL-8953897 Cellular responses to stimuli
Reactome:R-CEL-1234174 Cellular response to hypoxia
Reactome:R-CEL-3214847 HATs acetylate histones
Reactome:R-CEL-3700989 Transcriptional Regulation by TP53
Reactome:R-CEL-5633007 Regulation of TP53 Activity
Reactome:R-CEL-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Reactome:R-CEL-8878159 Transcriptional regulation by RUNX3
Reactome:R-DRE-5250913 Positive epigenetic regulation of rRNA expression
Reactome:R-DRE-392499 Metabolism of proteins
Reactome:R-DDI-3247509 Chromatin modifying enzymes
Reactome:R-DME-3247509 Chromatin modifying enzymes
Reactome:R-DME-195721 Signaling by WNT
Reactome:R-DME-201722 Formation of the beta-catenin:TCF transactivating complex
Reactome:R-DME-2559583 Cellular Senescence
Reactome:R-DME-5693606 DNA Double Strand Break Response
Reactome:R-DME-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome:R-HSA-400206 Regulation of lipid metabolism by PPARalpha
Reactome:R-HSA-194068 Bile acid and bile salt metabolism
Reactome:R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Reactome:R-HSA-211859 Biological oxidations
Reactome:R-HSA-5693532 DNA Double-Strand Break Repair
Reactome:R-HSA-5693538 Homology Directed Repair
Reactome:R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
Reactome:R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Reactome:R-HSA-9006936 Signaling by TGFB family members
Reactome:R-HSA-157118 Signaling by NOTCH
Reactome:R-HSA-1980145 Signaling by NOTCH2
Reactome:R-HSA-201681 TCF dependent signaling in response to WNT
Reactome:R-HSA-5683057 MAPK family signaling cascades
Reactome:R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor
Reactome:R-HSA-5578768 Physiological factors
Reactome:R-HSA-392499 Metabolism of proteins
Reactome:R-HSA-597592 Post-translational protein modification
Reactome:R-HSA-2990846 SUMOylation
Reactome:R-HSA-1643685 Disease
Reactome:R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome:R-HSA-162587 HIV Life Cycle
Reactome:R-HSA-167172 Transcription of the HIV genome
Reactome:R-HSA-74160 Gene expression (Transcription)
Reactome:R-HSA-73857 RNA Polymerase II Transcription
Reactome:R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
Reactome:R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes
Reactome:R-HSA-6804758 Regulation of TP53 Activity through Acetylation
Reactome:R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
Reactome:R-HSA-8941856 RUNX3 regulates NOTCH signaling
Reactome:R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
Reactome:R-HSA-76046 RNA Polymerase III Transcription Initiation
Reactome:R-HSA-918233 TRAF3-dependent IRF activation pathway
Reactome:R-MMU-5693548 Sensing of DNA Double Strand Breaks
Reactome:R-MMU-5693607 Processing of DNA double-strand break ends
Reactome:R-MMU-5693537 Resolution of D-Loop Structures
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-556833 Metabolism of lipids
Reactome:R-MMU-8957322 Metabolism of steroids
Reactome:R-MMU-211859 Biological oxidations
Reactome:R-MMU-1234174 Cellular response to hypoxia
Reactome:R-MMU-3214847 HATs acetylate histones
Reactome:R-MMU-74160 Gene expression (Transcription)
Reactome:R-MMU-73857 RNA Polymerase II Transcription
Reactome:R-MMU-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
Reactome:R-MMU-3700989 Transcriptional Regulation by TP53
Reactome:R-MMU-5633007 Regulation of TP53 Activity
Reactome:R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
Reactome:R-MMU-6811555 PI5P Regulates TP53 Acetylation
Reactome:R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Reactome:R-MMU-8941856 RUNX3 regulates NOTCH signaling
Reactome:R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
Reactome:R-MMU-76046 RNA Polymerase III Transcription Initiation
Reactome:R-MMU-212165 Epigenetic regulation of gene expression
Reactome:R-MMU-5250924 B-WICH complex positively regulates rRNA expression
Reactome:R-MMU-162582 Signaling Pathways
Reactome:R-MMU-8939211 ESR-mediated signaling
Reactome:R-MMU-3899300 SUMOylation of transcription cofactors
Reactome:R-RNO-6804758 Regulation of TP53 Activity through Acetylation
Reactome:R-RNO-8878171 Transcriptional regulation by RUNX1
Reactome:R-RNO-75953 RNA Polymerase II Transcription Initiation
Reactome:R-RNO-6807505 RNA polymerase II transcribes snRNA genes
Reactome:R-RNO-1234158 Regulation of gene expression by Hypoxia-inducible Factor
Reactome:R-RNO-162582 Signaling Pathways
Reactome:R-RNO-9006931 Signaling by Nuclear Receptors
Reactome:R-RNO-9018519 Estrogen-dependent gene expression
Reactome:R-RNO-5687128 MAPK6/MAPK4 signaling
Reactome:R-RNO-73894 DNA Repair
Reactome:R-RNO-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-RNO-5685942 HDR through Homologous Recombination (HRR)
Reactome:R-RNO-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
Reactome:R-RNO-1266738 Developmental Biology
Reactome:R-SCE-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-SCE-75953 RNA Polymerase II Transcription Initiation
Reactome:R-SCE-4839726 Chromatin organization
Reactome:R-SCE-8953897 Cellular responses to stimuli
Reactome:R-SPO-3247509 Chromatin modifying enzymes
Reactome:R-SPO-8939211 ESR-mediated signaling
Reactome:R-CEL-392499 Metabolism of proteins
Reactome:R-CEL-597592 Post-translational protein modification
Reactome:R-CEL-3899300 SUMOylation of transcription cofactors
Reactome:R-CEL-1266738 Developmental Biology
Reactome:R-CEL-3247509 Chromatin modifying enzymes
Reactome:R-CEL-212436 Generic Transcription Pathway
Reactome:R-DRE-212436 Generic Transcription Pathway
Reactome:R-DRE-5689901 Metalloprotease DUBs
Reactome:R-DDI-4839726 Chromatin organization
Reactome:R-DME-4839726 Chromatin organization
Reactome:R-DME-162582 Signaling Pathways
Reactome:R-DME-8953897 Cellular responses to stimuli
Reactome:R-DME-2559586 DNA Damage/Telomere Stress Induced Senescence
Reactome:R-DME-73894 DNA Repair
Reactome:R-DME-5693532 DNA Double-Strand Break Repair
Reactome:R-DME-5693538 Homology Directed Repair
Reactome:R-HSA-1266738 Developmental Biology
Reactome:R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
Reactome:R-HSA-556833 Metabolism of lipids
Reactome:R-HSA-211976 Endogenous sterols
Reactome:R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-HSA-5685942 HDR through Homologous Recombination (HRR)
Reactome:R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
Reactome:R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
Reactome:R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
Reactome:R-HSA-9012852 Signaling by NOTCH3
Reactome:R-HSA-9013694 Signaling by NOTCH4
Reactome:R-HSA-195721 Signaling by WNT
Reactome:R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
Reactome:R-HSA-9006931 Signaling by Nuclear Receptors
Reactome:R-HSA-9018519 Estrogen-dependent gene expression
Reactome:R-HSA-5687128 MAPK6/MAPK4 signaling
Reactome:R-HSA-2262752 Cellular responses to stress
Reactome:R-HSA-2559583 Cellular Senescence
Reactome:R-HSA-1640170 Cell Cycle
Reactome:R-HSA-453274 Mitotic G2-G2/M phases
Reactome:R-HSA-3899300 SUMOylation of transcription cofactors
Reactome:R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer
Reactome:R-HSA-162906 HIV Infection
Reactome:R-HSA-162599 Late Phase of HIV Life Cycle
Reactome:R-HSA-3214847 HATs acetylate histones
Reactome:R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes
Reactome:R-HSA-6804760 Regulation of TP53 Activity through Methylation
Reactome:R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors
Reactome:R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
Reactome:R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
Reactome:R-HSA-212165 Epigenetic regulation of gene expression
Reactome:R-HSA-5250924 B-WICH complex positively regulates rRNA expression
Reactome:R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome:R-MMU-5693606 DNA Double Strand Break Response
Reactome:R-MMU-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome:R-MMU-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
Reactome:R-MMU-5685938 HDR through Single Strand Annealing (SSA)
Reactome:R-MMU-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Reactome:R-MMU-211976 Endogenous sterols
Reactome:R-MMU-1234158 Regulation of gene expression by Hypoxia-inducible Factor
Reactome:R-MMU-3247509 Chromatin modifying enzymes
Reactome:R-MMU-6804758 Regulation of TP53 Activity through Acetylation
Reactome:R-MMU-8951936 RUNX3 regulates p14-ARF
Reactome:R-MMU-674695 RNA Polymerase II Pre-transcription Events
Reactome:R-MMU-73776 RNA Polymerase II Promoter Escape
Reactome:R-MMU-74158 RNA Polymerase III Transcription
Reactome:R-MMU-5250913 Positive epigenetic regulation of rRNA expression
Reactome:R-MMU-2122947 NOTCH1 Intracellular Domain Regulates Transcription
Reactome:R-MMU-5689901 Metalloprotease DUBs
Reactome:R-RNO-3214847 HATs acetylate histones
Reactome:R-RNO-350054 Notch-HLH transcription pathway
Reactome:R-RNO-8866907 Activation of the TFAP2 (AP-2) family of transcription factors
Reactome:R-RNO-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
Reactome:R-RNO-8878159 Transcriptional regulation by RUNX3
Reactome:R-RNO-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
Reactome:R-RNO-8953897 Cellular responses to stimuli
Reactome:R-RNO-2262752 Cellular responses to stress
Reactome:R-RNO-2559583 Cellular Senescence
Reactome:R-RNO-8939211 ESR-mediated signaling
Reactome:R-RNO-5693548 Sensing of DNA Double Strand Breaks
Reactome:R-RNO-5693607 Processing of DNA double-strand break ends
Reactome:R-RNO-5693537 Resolution of D-Loop Structures
Reactome:R-SCE-5693548 Sensing of DNA Double Strand Breaks
Reactome:R-SCE-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
Reactome:R-SCE-2559586 DNA Damage/Telomere Stress Induced Senescence
Reactome:R-SPO-4839726 Chromatin organization
Reactome:R-CEL-3108232 SUMO E3 ligases SUMOylate target proteins
Reactome:R-CEL-162582 Signaling Pathways
Reactome:R-CEL-195721 Signaling by WNT
Reactome:R-CEL-201681 TCF dependent signaling in response to WNT
Reactome:R-CEL-74160 Gene expression (Transcription)
Reactome:R-CEL-6804758 Regulation of TP53 Activity through Acetylation
Reactome:R-DRE-8878171 Transcriptional regulation by RUNX1
Reactome:R-DRE-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Reactome:R-DRE-212165 Epigenetic regulation of gene expression
Reactome:R-DRE-5250924 B-WICH complex positively regulates rRNA expression
Reactome:R-DDI-3214847 HATs acetylate histones
Reactome:R-DME-3214847 HATs acetylate histones
Reactome:R-DME-201681 TCF dependent signaling in response to WNT
Reactome:R-DME-2262752 Cellular responses to stress
Reactome:R-DME-5693548 Sensing of DNA Double Strand Breaks
Reactome:R-DME-5693607 Processing of DNA double-strand break ends
Reactome:R-DME-74160 Gene expression (Transcription)
Reactome:R-DME-212165 Epigenetic regulation of gene expression
Reactome:R-HSA-186712 Regulation of beta-cell development
Reactome:R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
Reactome:R-HSA-5619507 Activation of HOX genes during differentiation
Reactome:R-HSA-1989781 PPARA activates gene expression
Reactome:R-HSA-192105 Synthesis of bile acids and bile salts
Reactome:R-HSA-159418 Recycling of bile acids and salts
Reactome:R-HSA-211945 Phase I - Functionalization of compounds
Reactome:R-HSA-5693606 DNA Double Strand Break Response
Reactome:R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome:R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
Reactome:R-HSA-5685938 HDR through Single Strand Annealing (SSA)
Reactome:R-HSA-187037 Signaling by NTRK1 (TRKA)
Reactome:R-HSA-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-HSA-170834 Signaling by TGF-beta Receptor Complex
Reactome:R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Reactome:R-HSA-1912422 Pre-NOTCH Expression and Processing
Reactome:R-HSA-1980143 Signaling by NOTCH1
Reactome:R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription
Reactome:R-HSA-1234174 Cellular response to hypoxia
Reactome:R-HSA-5576891 Cardiac conduction
Reactome:R-HSA-69278 Cell Cycle, Mitotic
Reactome:R-HSA-69275 G2/M Transition
Reactome:R-HSA-156711 Polo-like kinase mediated events
Reactome:R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
Reactome:R-HSA-5688426 Deubiquitination
Reactome:R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression
Reactome:R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
Reactome:R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Reactome:R-HSA-167161 HIV Transcription Initiation
Reactome:R-HSA-4839726 Chromatin organization
Reactome:R-HSA-212436 Generic Transcription Pathway
Reactome:R-HSA-3700989 Transcriptional Regulation by TP53
Reactome:R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Reactome:R-HSA-5633007 Regulation of TP53 Activity
Reactome:R-HSA-6811555 PI5P Regulates TP53 Acetylation
Reactome:R-HSA-8878171 Transcriptional regulation by RUNX1
Reactome:R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Reactome:R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Reactome:R-HSA-8878159 Transcriptional regulation by RUNX3
Reactome:R-HSA-8951936 RUNX3 regulates p14-ARF
Reactome:R-HSA-75953 RNA Polymerase II Transcription Initiation
Reactome:R-HSA-6807505 RNA polymerase II transcribes snRNA genes
Reactome:R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
Reactome:R-HSA-168256 Immune System
Reactome:R-HSA-168249 Innate Immune System
Reactome:R-MMU-73894 DNA Repair
Reactome:R-MMU-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-MMU-5685942 HDR through Homologous Recombination (HRR)
Reactome:R-MMU-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
Reactome:R-MMU-5693571 Nonhomologous End-Joining (NHEJ)
Reactome:R-MMU-194068 Bile acid and bile salt metabolism
Reactome:R-MMU-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Reactome:R-MMU-211945 Phase I - Functionalization of compounds
Reactome:R-MMU-1266738 Developmental Biology
Reactome:R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence
Reactome:R-MMU-212436 Generic Transcription Pathway
Reactome:R-MMU-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Reactome:R-MMU-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
Reactome:R-MMU-8878159 Transcriptional regulation by RUNX3
Reactome:R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
Reactome:R-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
Reactome:R-MMU-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-MMU-157118 Signaling by NOTCH
Reactome:R-MMU-1980143 Signaling by NOTCH1
Reactome:R-MMU-9006931 Signaling by Nuclear Receptors
Reactome:R-MMU-9018519 Estrogen-dependent gene expression
Reactome:R-MMU-5687128 MAPK6/MAPK4 signaling
Reactome:R-MMU-392499 Metabolism of proteins
Reactome:R-MMU-597592 Post-translational protein modification
Reactome:R-MMU-2990846 SUMOylation
Reactome:R-RNO-4839726 Chromatin organization
Reactome:R-RNO-74160 Gene expression (Transcription)
Reactome:R-RNO-73857 RNA Polymerase II Transcription
Reactome:R-RNO-3700989 Transcriptional Regulation by TP53
Reactome:R-RNO-5633007 Regulation of TP53 Activity
Reactome:R-RNO-674695 RNA Polymerase II Pre-transcription Events
Reactome:R-RNO-73776 RNA Polymerase II Promoter Escape
Reactome:R-RNO-1234174 Cellular response to hypoxia
Reactome:R-RNO-5683057 MAPK family signaling cascades
Reactome:R-RNO-5693532 DNA Double-Strand Break Repair
Reactome:R-RNO-5693538 Homology Directed Repair
Reactome:R-RNO-5693579 Homologous DNA Pairing and Strand Exchange
Reactome:R-SCE-5693532 DNA Double-Strand Break Repair
Reactome:R-SCE-674695 RNA Polymerase II Pre-transcription Events
Reactome:R-SCE-73776 RNA Polymerase II Promoter Escape
Reactome:R-SCE-3247509 Chromatin modifying enzymes
Reactome:R-SCE-2559583 Cellular Senescence
Reactome:R-SPO-3214847 HATs acetylate histones
Reactome:R-SPO-162582 Signaling Pathways
Reactome:R-SPO-9006931 Signaling by Nuclear Receptors
Reactome:R-SPO-9018519 Estrogen-dependent gene expression
Reactome:R-CEL-2262752 Cellular responses to stress
Reactome:R-CEL-1234158 Regulation of gene expression by Hypoxia-inducible Factor
Reactome:R-CEL-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-CEL-4839726 Chromatin organization
Reactome:R-CEL-73857 RNA Polymerase II Transcription
Reactome:R-CEL-8878171 Transcriptional regulation by RUNX1
Reactome:R-DRE-74160 Gene expression (Transcription)
Reactome:R-DRE-73857 RNA Polymerase II Transcription
Reactome:R-DRE-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
Reactome:R-DRE-597592 Post-translational protein modification
Reactome:R-DRE-5688426 Deubiquitination
Reactome:R-DME-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-8957322 Metabolism of steroids
Reactome:R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Reactome:R-HSA-211897 Cytochrome P450 - arranged by substrate type
Reactome:R-HSA-73894 DNA Repair
Reactome:R-HSA-5693548 Sensing of DNA Double Strand Breaks
Reactome:R-HSA-5693607 Processing of DNA double-strand break ends
Reactome:R-HSA-5693537 Resolution of D-Loop Structures
Reactome:R-HSA-162582 Signaling Pathways
Reactome:R-HSA-166520 Signaling by NTRKs
Reactome:R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Reactome:R-HSA-1912408 Pre-NOTCH Transcription and Translation
Reactome:R-HSA-2197563 NOTCH2 intracellular domain regulates transcription
Reactome:R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
Reactome:R-HSA-8939211 ESR-mediated signaling
Reactome:R-HSA-8953897 Cellular responses to stimuli
Reactome:R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
Reactome:R-HSA-397014 Muscle contraction
Reactome:R-HSA-5689901 Metalloprotease DUBs
Reactome:R-HSA-2644603 Signaling by NOTCH1 in Cancer
Reactome:R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome:R-HSA-5663205 Infectious disease
Reactome:R-HSA-167162 RNA Polymerase II HIV Promoter Escape
Reactome:R-HSA-3247509 Chromatin modifying enzymes
Reactome:R-HSA-350054 Notch-HLH transcription pathway
Reactome:R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Reactome:R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Reactome:R-HSA-8941858 Regulation of RUNX3 expression and activity
Reactome:R-HSA-674695 RNA Polymerase II Pre-transcription Events
Reactome:R-HSA-73776 RNA Polymerase II Promoter Escape
Reactome:R-HSA-74158 RNA Polymerase III Transcription
Reactome:R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
Reactome:R-HSA-5250913 Positive epigenetic regulation of rRNA expression
Reactome:R-MMU-5693532 DNA Double-Strand Break Repair
Reactome:R-MMU-5693538 Homology Directed Repair
Reactome:R-MMU-5693579 Homologous DNA Pairing and Strand Exchange
Reactome:R-MMU-192105 Synthesis of bile acids and bile salts
Reactome:R-MMU-159418 Recycling of bile acids and salts
Reactome:R-MMU-211897 Cytochrome P450 - arranged by substrate type
Reactome:R-MMU-8953897 Cellular responses to stimuli
Reactome:R-MMU-2262752 Cellular responses to stress
Reactome:R-MMU-2559583 Cellular Senescence
Reactome:R-MMU-4839726 Chromatin organization
Reactome:R-MMU-350054 Notch-HLH transcription pathway
Reactome:R-MMU-6804760 Regulation of TP53 Activity through Methylation
Reactome:R-MMU-8866907 Activation of the TFAP2 (AP-2) family of transcription factors
Reactome:R-MMU-8878171 Transcriptional regulation by RUNX1
Reactome:R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Reactome:R-MMU-8941858 Regulation of RUNX3 expression and activity
Reactome:R-MMU-75953 RNA Polymerase II Transcription Initiation
Reactome:R-MMU-6807505 RNA polymerase II transcribes snRNA genes
Reactome:R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
Reactome:R-MMU-5683057 MAPK family signaling cascades
Reactome:R-MMU-3108232 SUMO E3 ligases SUMOylate target proteins
Reactome:R-MMU-5688426 Deubiquitination
Reactome:R-RNO-3247509 Chromatin modifying enzymes
Reactome:R-RNO-212436 Generic Transcription Pathway
Reactome:R-RNO-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Reactome:R-RNO-8941856 RUNX3 regulates NOTCH signaling
Reactome:R-RNO-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
Reactome:R-RNO-212165 Epigenetic regulation of gene expression
Reactome:R-RNO-2559586 DNA Damage/Telomere Stress Induced Senescence
Reactome:R-RNO-5693606 DNA Double Strand Break Response
Reactome:R-RNO-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome:R-RNO-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
Reactome:R-RNO-5685938 HDR through Single Strand Annealing (SSA)
Reactome:R-SCE-73894 DNA Repair
Reactome:R-SCE-5693606 DNA Double Strand Break Response
Reactome:R-SCE-74160 Gene expression (Transcription)
Reactome:R-SCE-73857 RNA Polymerase II Transcription
Reactome:R-SCE-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
Reactome:R-SCE-3214847 HATs acetylate histones
Reactome:R-SCE-2262752 Cellular responses to stress
WikiPathways:WP5381 Smith-Magenis and Potocki-Lupski syndrome copy number variation
WikiPathways:WP3959 DNA IR-double strand breaks and cellular response via ATM
PathBank:SMP0119374 Circadian Rhythms
PathBank:SMP0084271 NAD+ Signalling and Aging
PathBank:SMP0120950 NF-kB Signaling Pathway
PathBank:SMP0090831 Circadian Rhythms
PathBank:SMP0063813 NF-kB Signaling Pathway