EC: 2.1.1.6

catechol O-methyltransferase (S-adenosyl-L-methionine:catechol O-methyltransferase)

enzyme lambda metabolic reaction experiment
uniprot:P22734 [BIA 3-335]

L_Adrenaline + S_Adenosyl_L_methionine -> L_Metanephrine + S_Adenosyl_L_homocysteine		 (( (( (( (kcat * A) ) / 2) ) * (Km + A)) ) * (( (( (( (e * E) ) - Kii) ) - I) ) + (( (( (( (( (Kii + I) ) + (e * E)) ) ^ 2) ) - (( (( (4 * I) ) * e) ) * E)) ) ^ 1/2))) buffer: 10 mM Sodium phosphate, 1 mM EGTA
PH: 7.2
Temperature: 36
uniprot:P22734 [Mg2+]

S_Adenosyl_L_methionine + L_Adrenaline -> L_Metanephrine + S_Adenosyl_L_homocysteine		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Sodium phosphate, 1 mM EGTA
PH: 7.2
Temperature: 36
uniprot:P22734 [Mg2+]

L_Adrenaline + S_Adenosyl_L_methionine -> L_Metanephrine + S_Adenosyl_L_homocysteine		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Sodium phosphate, 1 mM EGTA
PH: 7.2
Temperature: 36

Pathways

pathway id name
BioCyc:META_PWY6666-2 dopamine degradation
BioCyc:META_PWY-6342 noradrenaline and adrenaline degradation
BioCyc:META_PWY-6334 L-dopa degradation
BioCyc:MOUSE_PWY6666-2 dopamine degradation
BioCyc:HUMAN_PWY6666-2 dopamine degradation
BioCyc:HUMAN_PWY-6334 L-dopa degradation
BioCyc:HUMAN_PWY-6342 noradrenaline and adrenaline degradation
Reactome:R-HSA-9679506 SARS-CoV Infections
Reactome:R-HSA-9679191 Potential therapeutics for SARS
Reactome:R-HSA-9824446 Viral Infection Pathways
Reactome:R-BTA-1430728 Metabolism
Reactome:R-BTA-379397 Enzymatic degradation of dopamine by COMT
Reactome:R-DRE-112315 Transmission across Chemical Synapses
Reactome:R-DRE-112311 Neurotransmitter clearance
Reactome:R-HSA-211859 Biological oxidations
Reactome:R-HSA-156581 Methylation
Reactome:R-HSA-112315 Transmission across Chemical Synapses
Reactome:R-HSA-112311 Neurotransmitter clearance
Reactome:R-HSA-1643685 Disease
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-211859 Biological oxidations
Reactome:R-MMU-156581 Methylation
Reactome:R-MMU-379398 Enzymatic degradation of Dopamine by monoamine oxidase
Reactome:R-RNO-112316 Neuronal System
Reactome:R-RNO-379401 Clearance of dopamine
Reactome:R-BTA-211859 Biological oxidations
Reactome:R-BTA-156581 Methylation
Reactome:R-BTA-112316 Neuronal System
Reactome:R-BTA-379401 Clearance of dopamine
Reactome:R-DRE-379398 Enzymatic degradation of Dopamine by monoamine oxidase
Reactome:R-HSA-156580 Phase II - Conjugation of compounds
Reactome:R-HSA-379398 Enzymatic degradation of Dopamine by monoamine oxidase
Reactome:R-MMU-156580 Phase II - Conjugation of compounds
Reactome:R-MMU-379397 Enzymatic degradation of dopamine by COMT
Reactome:R-RNO-211859 Biological oxidations
Reactome:R-RNO-156581 Methylation
Reactome:R-RNO-112315 Transmission across Chemical Synapses
Reactome:R-RNO-112311 Neurotransmitter clearance
Reactome:R-BTA-379398 Enzymatic degradation of Dopamine by monoamine oxidase
Reactome:R-DRE-112316 Neuronal System
Reactome:R-DRE-379401 Clearance of dopamine
Reactome:R-DRE-1430728 Metabolism
Reactome:R-DRE-156580 Phase II - Conjugation of compounds
Reactome:R-HSA-112316 Neuronal System
Reactome:R-HSA-379401 Clearance of dopamine
Reactome:R-MMU-112315 Transmission across Chemical Synapses
Reactome:R-MMU-112311 Neurotransmitter clearance
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-379397 Enzymatic degradation of dopamine by COMT
Reactome:R-BTA-156580 Phase II - Conjugation of compounds
Reactome:R-BTA-112315 Transmission across Chemical Synapses
Reactome:R-BTA-112311 Neurotransmitter clearance
Reactome:R-DRE-379397 Enzymatic degradation of dopamine by COMT
Reactome:R-DRE-211859 Biological oxidations
Reactome:R-DRE-156581 Methylation
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-379397 Enzymatic degradation of dopamine by COMT
Reactome:R-HSA-5663205 Infectious disease
Reactome:R-MMU-112316 Neuronal System
Reactome:R-MMU-379401 Clearance of dopamine
Reactome:R-RNO-156580 Phase II - Conjugation of compounds
Reactome:R-RNO-379398 Enzymatic degradation of Dopamine by monoamine oxidase
WikiPathways:WP4220 Neurotransmitter disorders
WikiPathways:WP4156 Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine
PathBank:SMP0120674 Alkaptonuria
PathBank:SMP0120782 Dopamine beta-Hydroxylase Deficiency
PathBank:SMP0000190 Hawkinsinuria
PathBank:SMP0000327 Phenytoin (Antiarrhythmic) Action Pathway
PathBank:SMP0120729 Tyrosinemia Type I
PathBank:SMP0120817 Monoamine Oxidase-A Deficiency (MAO-A)
PathBank:SMP0120491 Hawkinsinuria
PathBank:SMP0000169 Alkaptonuria
PathBank:SMP0000429 Disulfiram Action Pathway
PathBank:SMP0087365 Estrone Metabolism
PathBank:SMP0063684 Tyrosine Metabolism
PathBank:SMP0120453 Alkaptonuria
PathBank:SMP0120509 Tyrosinemia Type I
PathBank:SMP0120598 Monoamine Oxidase-A Deficiency (MAO-A)
PathBank:SMP0000218 Tyrosinemia Type I
PathBank:SMP0000533 Monoamine Oxidase-A Deficiency (MAO-A)
PathBank:SMP0087272 Estrone Metabolism
PathBank:SMP0087328 Tyrosine Metabolism
PathBank:SMP0120711 Hawkinsinuria
PathBank:SMP0120779 Tyrosinemia, Transient, of the Newborn
PathBank:SMP0030880 Estrone Metabolism
PathBank:SMP0120559 Tyrosinemia, Transient, of the Newborn
PathBank:SMP0120563 Dopamine beta-Hydroxylase Deficiency
PathBank:SMP0000006 Tyrosine Metabolism
PathBank:SMP0000494 Tyrosinemia, Transient, of the Newborn
PathBank:SMP0000498 Dopamine beta-Hydroxylase Deficiency
PathBank:SMP0087235 Tyrosine Metabolism
PathBank:SMP0063696 Estrone Metabolism