EC: 1.5.1.7

saccharopine dehydrogenase (NAD+, L-lysine-forming) (N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming))

enzyme lambda metabolic reaction experiment
uniprot:P38998 [saccharopine dehydrogenase (NAD+, L-lysine-forming)(Enzyme) wildtype His-tagged]

NADH + 2_Oxoglutarate + H+ + L_Lysine -> N6_(L_1,3_Dicarboxypropyl)_L_lysine + H2O + NAD+
(( (( (( (( (kcat * E) ) * A) ) * B) ) * C) ) / (( (( (( (( (c + (coefA * A)) ) + (( (Kc * A) ) * B)) ) + (( (Kb * A) ) * C)) ) + (( (Ka * B) ) * C)) ) + (( (A * B) ) * C))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [saccharopine dehydrogenase (NAD+, L-lysine-forming)(Enzyme) wildtype His-tagged]

NAD+ + H2O + N6_(L_1,3_Dicarboxypropyl)_L_lysine -> 2_Oxoglutarate + H+ + L_Lysine + NADH
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (( (Kia * Kb) ) + (Ka * B)) ) + (Kb * A)) ) + (A * B))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [saccharopine dehydrogenase (NAD+, L-lysine-forming)(Enzyme) wildtype His-tagged]

L_Lysine + NADH + 2_Oxoglutarate + H+ -> N6_(L_1,3_Dicarboxypropyl)_L_lysine + NAD+ + H2O
(( (( (kcat * E) ) * A) ) / (Ka + (A * (1 + (I / Ki))))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [saccharopine dehydrogenase (NAD+, L-lysine-forming)(Enzyme) wildtype His-tagged]

L_Lysine + H+ + NADH + 2_Oxoglutarate -> H2O + N6_(L_1,3_Dicarboxypropyl)_L_lysine + NAD+
(( (( (kcat * E) ) * A) ) / (Ka + (A * (1 + (I / Ki))))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [saccharopine dehydrogenase (NAD+, L-lysine-forming)(Enzyme) wildtype His-tagged]

NAD+ + N6_(L_1,3_Dicarboxypropyl)_L_lysine + H2O -> NADH + 2_Oxoglutarate + H+ + L_Lysine
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Ki))) ) + A)) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [saccharopine dehydrogenase (NAD+, L-lysine-forming)(Enzyme) wildtype His-tagged]

H2O + N6_(L_1,3_Dicarboxypropyl)_L_lysine + NAD+ -> 2_Oxoglutarate + L_Lysine + H+ + NADH
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Kis))) ) + (A * (1 + (I / Kii))))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [saccharopine dehydrogenase (NAD+, L-lysine-forming)(Enzyme) wildtype His-tagged]

L_Lysine + 2_Oxoglutarate + NADH + H+ -> N6_(L_1,3_Dicarboxypropyl)_L_lysine + H2O + NAD+
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Kis))) ) + (A * (1 + (I / Kii))))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [saccharopine dehydrogenase (NAD+, L-lysine-forming)(Enzyme) wildtype His-tagged]

NADH + 2_Oxoglutarate + L_Lysine + H+ -> NAD+ + N6_(L_1,3_Dicarboxypropyl)_L_lysine + H2O
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Kis))) ) + (A * (1 + (I / Kii))))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [saccharopine dehydrogenase (NAD+, L-lysine-forming)(Enzyme) wildtype His-tagged]

H+ + NADH + L_Lysine + 2_Oxoglutarate -> N6_(L_1,3_Dicarboxypropyl)_L_lysine + NAD+ + H2O
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Kis))) ) + (A * (1 + (I / Kii))))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [saccharopine dehydrogenase (NAD+, L-lysine-forming)(Enzyme) wildtype His-tagged]

NAD+ + N6_(L_1,3_Dicarboxypropyl)_L_lysine + H2O -> L_Lysine + H+ + NADH + 2_Oxoglutarate
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Kis))) ) + (A * (1 + (I / Kii))))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [saccharopine dehydrogenase (NAD+, L-lysine-forming)(Enzyme) wildtype His-tagged]

L_Lysine + NADH + 2_Oxoglutarate + H+ -> H2O + NAD+ + N6_(L_1,3_Dicarboxypropyl)_L_lysine
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Kis))) ) + (A * (1 + (I / Kii))))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [saccharopine dehydrogenase (NAD+, L-lysine-forming)(Enzyme) wildtype His-tagged]

N6_(L_1,3_Dicarboxypropyl)_L_lysine + NAD+ + H2O -> L_Lysine + H+ + NADH + 2_Oxoglutarate
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Ki))) ) + A)) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [saccharopine dehydrogenase (NAD+, L-lysine-forming)(Enzyme) wildtype His-tagged]

2_Oxoglutarate + H+ + NADH + L_Lysine -> N6_(L_1,3_Dicarboxypropyl)_L_lysine + H2O + NAD+
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Ki))) ) + A)) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [saccharopine dehydrogenase (NAD+, L-lysine-forming)(Enzyme) wildtype His-tagged]

H2O + N6_(L_1,3_Dicarboxypropyl)_L_lysine + NAD+ -> NADH + L_Lysine + 2_Oxoglutarate + H+
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Ki))) ) + A)) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [L-Leucine]

NADH + H+ + 2_Oxoglutarate + L_Lysine -> N6_(L_1,3_Dicarboxypropyl)_L_lysine + NAD+ + H2O
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Kis))) ) + (A * (1 + (I / Kii))))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [Oxaloacetate]

NADH + H+ + L_Lysine + 2_Oxoglutarate -> N6_(L_1,3_Dicarboxypropyl)_L_lysine + H2O + NAD+
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Kis))) ) + (A * (1 + (I / Kii))))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [L-Leucine]

L_Lysine + 2_Oxoglutarate + NADH + H+ -> H2O + N6_(L_1,3_Dicarboxypropyl)_L_lysine + NAD+
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Ki))) ) + A)) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [L-Leucine]

L_Lysine + H+ + 2_Oxoglutarate + NADH -> H2O + N6_(L_1,3_Dicarboxypropyl)_L_lysine + NAD+
(( (( (kcat * E) ) * A) ) / (Ka + (A * (1 + (I / Ki))))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [Oxaloacetate]

NADH + 2_Oxoglutarate + H+ + L_Lysine -> NAD+ + H2O + N6_(L_1,3_Dicarboxypropyl)_L_lysine
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Ki))) ) + A)) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [N-Oxaloglycine]

2_Oxoglutarate + NADH + H+ + L_Lysine -> H2O + NAD+ + N6_(L_1,3_Dicarboxypropyl)_L_lysine
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Kis))) ) + (A * (1 + (I / Kii))))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [N-Oxaloglycine]

2_Oxoglutarate + L_Lysine + NADH + H+ -> NAD+ + N6_(L_1,3_Dicarboxypropyl)_L_lysine + H2O
(( (( (kcat * E) ) * A) ) / (Ka + (A * (1 + (I / Ki))))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [N-Oxaloglycine]

L_Lysine + NADH + H+ + 2_Oxoglutarate -> NAD+ + N6_(L_1,3_Dicarboxypropyl)_L_lysine + H2O
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Ki))) ) + A)) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [saccharopine dehydrogenase (NAD+, L-lysine-forming)(Enzyme) wildtype His-tagged]

N6_(L_1,3_Dicarboxypropyl)_L_lysine + NAD+ + H2O -> L_Lysine + H+ + 2_Oxoglutarate + NADH
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Kis))) ) + (A * (1 + (I / Kii))))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [Oxaloacetate]

H+ + NADH + 2_Oxoglutarate + L_Lysine -> H2O + N6_(L_1,3_Dicarboxypropyl)_L_lysine + NAD+
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Kis))) ) + (A * (1 + (I / Kii))))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [saccharopine dehydrogenase (NAD+, L-lysine-forming)(Enzyme) wildtype His-tagged]

NADH + H+ + L_Lysine + 2_Oxoglutarate -> N6_(L_1,3_Dicarboxypropyl)_L_lysine + H2O + NAD+
(( (( (( (( (kcat * E) ) * A) ) * B) ) * C) ) / (( (( (( (( (( (( (Kia * Kib) ) * Kc) ) + (( (Kib * Kc) ) * A)) ) + (( (Kb * A) ) * C)) ) + (( (Kc * A) ) * B)) ) + (( (Ka * B) ) * C)) ) + (( (A * B) ) * C))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [Glutarate]

H+ + 2_Oxoglutarate + NADH + L_Lysine -> NAD+ + H2O + N6_(L_1,3_Dicarboxypropyl)_L_lysine
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (( (I ^ 2) ) / (Kis ^ 2)))) ) + (A * (1 + (I / Kii))))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [Glutarate]

NADH + L_Lysine + H+ + 2_Oxoglutarate -> N6_(L_1,3_Dicarboxypropyl)_L_lysine + NAD+ + H2O
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Kis))) ) + (A * (1 + (I / Kii))))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [Pyruvate]

L_Lysine + NADH + H+ + 2_Oxoglutarate -> N6_(L_1,3_Dicarboxypropyl)_L_lysine + H2O + NAD+
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Ki))) ) + A)) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [Pyruvate]

NADH + H+ + 2_Oxoglutarate + L_Lysine -> N6_(L_1,3_Dicarboxypropyl)_L_lysine + H2O + NAD+
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Ki))) ) + A)) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [Pyruvate]

H+ + L_Lysine + NADH + 2_Oxoglutarate -> H2O + NAD+ + N6_(L_1,3_Dicarboxypropyl)_L_lysine
(( (( (kcat * E) ) * A) ) / (Ka + (A * (1 + (I / Ki))))) buffer: 100 mM Hepes
PH: 7
Temperature: 25
uniprot:P38998 [Glutarate]

H+ + NADH + 2_Oxoglutarate + L_Lysine -> NAD+ + N6_(L_1,3_Dicarboxypropyl)_L_lysine + H2O
(( (( (kcat * E) ) * A) ) / (( (Ka * (1 + (I / Ki))) ) + A)) buffer: 100 mM Hepes
PH: 7
Temperature: 25

Pathways

pathway id name
BioCyc:YEAST_LYSINE-AMINOAD-PWY L-lysine biosynthesis IV
PathBank:SMP0002337 Lysine Metabolism