EC: 6.3.2.11

carnosine synthase (L-histidine:beta-alanine ligase (ADP-forming))

enzyme lambda metabolic reaction experiment
- [carnosine synthase(Enzyme) wildtype]

L_Histidine + ATP + 4_Aminobutanoate -> Homocarnosine + AMP + Diphosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM Tris-HCl, 4 mM MgCl2, 0.2 mM NAD, 2 mM dithiothreitol, 7.5 mM NaHCO3, 8 mM glucose
PH: 7.4
Temperature: 37
- [carnosine synthase(Enzyme) wildtype]

ATP + L_Histidine + beta_Alanine -> AMP + Diphosphate + Carnosine		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM Tris-HCl, 4 mM MgCl2, 0.2 mM NAD, 2 mM dithiothreitol, 7.5 mM NaHCO3, 8 mM glucose
PH: 7.4
Temperature: 37

Pathways

pathway id name
BioCyc:HUMAN_PWY66-421 homocarnosine biosynthesis
BioCyc:META_PWY66-421 homocarnosine biosynthesis
BioCyc:HUMAN_PWY66-420 carnosine biosynthesis
BioCyc:META_PWY66-420 carnosine biosynthesis
Reactome:R-MMU-1430728 Metabolism
Reactome:R-HSA-70921 Histidine catabolism
Reactome:R-MMU-70921 Histidine catabolism
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-HSA-1430728 Metabolism
PathBank:SMP0120493 Histidinemia
PathBank:SMP0000044 Histidine Metabolism
PathBank:SMP0000191 Histidinemia
PathBank:SMP0063632 Histidine Metabolism