EC: 4.1.1.22

histidine decarboxylase (L-histidine carboxy-lyase (histamine-forming))

enzyme lambda metabolic reaction experiment
uniprot:P00862 [histidine decarboxylase(Enzyme) mutant E66Q]

L_Histidine -> CO2 + Histamine
(( (( (kcat * E) ) * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Citrate, 0.2 M Na2HPO4
PH: 4.8
Temperature: 37
uniprot:P00862 [histidine decarboxylase(Enzyme) mutant S82C]

L_Histidine -> Histamine + CO2
(( (Vmax * A) ) / (Km + A)) buffer: 0.1 M Citrate, 0.2 M Na2HPO4
PH: 4.8
Temperature: 37
uniprot:P00862 [histidine decarboxylase(Enzyme) mutant E66Q]

L_Histidine -> Histamine + CO2
(( (( (kcat * E) ) * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Citrate, 0.2 M Na2HPO4
PH: 7.6
Temperature: 37
uniprot:P00862 [histidine decarboxylase(Enzyme) wildtype]

L_Histidine -> Histamine + CO2
(( (( (kcat * E) ) * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Citrate, 0.2 M Na2HPO4
PH: 7
Temperature: 37
uniprot:P00862 [histidine decarboxylase(Enzyme) wildtype]

L_Histidine -> CO2 + Histamine
(( (( (kcat * E) ) * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Citrate, 0.2 M Na2HPO4
PH: 7.6
Temperature: 37
uniprot:P00862 [histidine decarboxylase(Enzyme) wildtype]

L_Histidine -> Histamine + CO2
(( (Vmax * A) ) / (Km + A)) buffer: 0.1 M Citrate, 0.2 M Na2HPO4
PH: 4.8
Temperature: 37
uniprot:P00862 [histidine decarboxylase(Enzyme) mutant E197D]

L_Histidine -> Histamine + CO2
(( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 0.1 M Citrate, 0.2 M Na2HPO4
PH: 4.8
Temperature: 37
uniprot:P00862 [histidine decarboxylase(Enzyme) wildtype]

L_Histidine -> Histamine + CO2
(( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 0.1 M Citrate, 0.2 M Na2HPO4
PH: 4.8
Temperature: 37
uniprot:P00862 [histidine decarboxylase(Enzyme) mutant E197Q]

L_Histidine -> CO2 + Histamine
(( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 0.1 M Citrate, 0.2 M Na2HPO4
PH: 4.8
Temperature: 37
uniprot:P00862 [histidine decarboxylase(Enzyme) mutant S82T]

L_Histidine -> CO2 + Histamine
(( (Vmax * A) ) / (Km + A)) buffer: 0.1 M Citrate, 0.2 M Na2HPO4
PH: 4.8
Temperature: 37
uniprot:P04193 [histidine decarboxylase(Enzyme) wildtype]

L_Histidine -> CO2 + Histamine
(( (Vmax * S) ) / (Km + S)) buffer: 0.2 M Ammonium acetate
PH: 5
Temperature: 36
uniprot:Q0TU55 [histidine decarboxylase(Enzyme) wildtype]

L_Histidine -> Histamine + CO2
(( (Vmax * A) ) / (Km + A)) buffer: 0.2 M Ammonium acetate, 1 mM Dithiothreitol
PH: 4.5
Temperature: 37
- [histidine decarboxylase(Enzyme) wildtype]

L_Histidine -> Histamine + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 0.1 M Citric acid, 0.2 M Dibasic potassium phosphate
PH: 4.8
Temperature: 37
- [histidine decarboxylase(Enzyme) wildtype]

L_Histidine -> Histamine + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 0.1 M Citric acid, 0.2 M Dibasic potassium phosphate
PH: 4.8
Temperature: 37
uniprot:O66000 [Pyridoxal phosphate]

L_Histidine -> CO2 + Histamine
(( (Vmax * S) ) / (Km + S)) buffer: 0.2 M ammonium acetate
PH: 4.8
Temperature: 37
uniprot:O66000 [Pyridoxal phosphate]

L_Histidine -> Histamine + CO2
(( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.2 M phosphate
PH: 7.6
Temperature: 37
uniprot:P05034 [histidine decarboxylase(Enzyme) wildtype]

alpha_Methylhistidine -> 2_(1H_Imidazol_4_yl)_1_methyl_ethylamine + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Potassium phosphate, 0.03 mM Pyridoxal phosphate
PH: 6.5
Temperature: 37
uniprot:P00862 [histidine decarboxylase(Enzyme) wildtype]

L_Histidine -> CO2 + Histamine
(( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 0.1 M Citrate, 0.2 M Na2HPO4
PH: 4.8
Temperature: 37
uniprot:P00862 [histidine decarboxylase(Enzyme) mutant G58D]

L_Histidine -> Histamine + CO2
(( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 0.1 M Citrate, 0.2 M Na2HPO4
PH: 4.8
Temperature: 37
uniprot:P19113 [Pyridoxal phosphate]

L_Dopa -> CO2 + Dopamine
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 0.1 M potassium phosphate, 0.1 mM dithiothreitol
PH: 6.8
Temperature: 37
uniprot:P19113 [Pyridoxal phosphate]

L_Histidine -> CO2 + Histamine
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 0.1 M potassium phosphate, 0.1 mM dithiothreitol
PH: 6.8
Temperature: 37
uniprot:P19113 [Pyridoxal phosphate]

L_Histidine -> Histamine + CO2
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 0.1 M potassium phosphate, 0.1 mM dithiothreitol
PH: 6.8
Temperature: 37
uniprot:P19113 [Pyridoxal phosphate]

L_Histidine -> CO2 + Histamine
(( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 0.1 M potassium phosphate, 0.1 mM dithiothreitol
PH: 6.8
Temperature: 37
uniprot:P23738 [Pyridoxal phosphate]

L_Histidine -> CO2 + Histamine
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM potassium phosphate, 0.2 mM DTT, 10 mg/ml PEG300
PH: 6.8
Temperature: 37
uniprot:P23738 [Pyridoxal phosphate]

L_Histidine -> Histamine + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM potassium phosphate, 0.2 mM dithiothreitol, 10 mg/ml polyethylene glycol No. 300
PH: 6.8
Temperature: 37

Pathways

pathway id name
BioCyc:META_PWY-6173 histamine biosynthesis
BioCyc:HUMAN_PWY-6173 histamine biosynthesis
BioCyc:MOUSE_PWY-6173 histamine biosynthesis
Reactome:R-BTA-1430728 Metabolism
Reactome:R-BTA-71291 Amino acid and derivative metabolism
Reactome:R-MMU-1430728 Metabolism
Reactome:R-DME-1430728 Metabolism
Reactome:R-DME-71291 Amino acid and derivative metabolism
Reactome:R-HSA-70921 Histidine catabolism
Reactome:R-MMU-70921 Histidine catabolism
Reactome:R-RNO-70921 Histidine catabolism
Reactome:R-DME-70921 Histidine catabolism
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-71291 Amino acid and derivative metabolism
Reactome:R-BTA-70921 Histidine catabolism
Reactome:R-HSA-1430728 Metabolism
PathBank:SMP0120666 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0120698 GABA-Transaminase Deficiency
PathBank:SMP0120714 Homocarnosinosis
PathBank:SMP0120722 Hypoacetylaspartia
PathBank:SMP0120778 Carnosinuria, Carnosinemia
PathBank:SMP0120850 Succinic Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0087278 Glutamate Metabolism
PathBank:SMP0087314 Histidine Metabolism
PathBank:SMP0120681 Canavan Disease
PathBank:SMP0120713 Histidinemia
PathBank:SMP0120777 Ureidopropionase Deficiency
PathBank:SMP0087309 Taurine and Hypotaurine Metabolism
PathBank:SMP0120716 Hyperinsulinism-Hyperammonemia Syndrome
PathBank:SMP0000044 Histidine Metabolism
PathBank:SMP0000191 Histidinemia
PathBank:SMP0087219 Histidine Metabolism
PathBank:SMP0087276 Aspartate Metabolism
PathBank:SMP0087284 beta-Alanine Metabolism
PathBank:SMP0120659 2-Hydroxyglutric Aciduria (D and L Form)