EC: 3.4.21.5

thrombin ()

enzyme lambda metabolic reaction experiment
uniprot:P00734 [thrombin(Enzyme) wildtype]

H_D_Ile_Pro_Arg_p_nitroanilide + H2O -> H_D_Ile_Pro_Arg + 4_Nitroaniline		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 20 mM Hepes, 0.15 M NaCl, 0.01 % BSA, 2 % DMSO, 1 % DMF
PH: 7.5
Temperature: 25

Pathways

pathway id name
Reactome:R-HSA-9657688 Defective factor XII causes hereditary angioedema
Reactome:R-HSA-9671793 Diseases of hemostasis
Reactome:R-HSA-9662001 Defective factor VIII causes hemophilia A
Reactome:R-HSA-9824446 Viral Infection Pathways
Reactome:R-HSA-9651496 Defects of Formation of Fibrin Clot (Clotting Cascade)
Reactome:R-HSA-9672391 Defective F8 cleavage by thrombin
Reactome:R-HSA-9839923 Dengue Virus Infection
Reactome:R-HSA-9918481 Dengue Virus-Host Interactions
Reactome:R-HSA-140875 Common Pathway of Fibrin Clot Formation
Reactome:R-HSA-500792 GPCR ligand binding
Reactome:R-HSA-392499 Metabolism of proteins
Reactome:R-HSA-597592 Post-translational protein modification
Reactome:R-HSA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Reactome:R-HSA-381426 Regulation of IGF Activity by IGFBP
Reactome:R-HSA-1643685 Disease
Reactome:R-MMU-76002 Platelet activation, signaling and aggregation
Reactome:R-MMU-76009 Platelet Aggregation (Plug Formation)
Reactome:R-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation
Reactome:R-MMU-162582 Signaling Pathways
Reactome:R-MMU-375276 Peptide ligand-binding receptors
Reactome:R-MMU-159740 Gamma-carboxylation of protein precursors
Reactome:R-RNO-597592 Post-translational protein modification
Reactome:R-RNO-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Reactome:R-RNO-381426 Regulation of IGF Activity by IGFBP
Reactome:R-RNO-162582 Signaling Pathways
Reactome:R-RNO-372790 Signaling by GPCR
Reactome:R-RNO-109582 Hemostasis
Reactome:R-RNO-456926 Thrombin signalling through proteinase activated receptors (PARs)
Reactome:R-RNO-202733 Cell surface interactions at the vascular wall
Reactome:R-HSA-76002 Platelet activation, signaling and aggregation
Reactome:R-HSA-76009 Platelet Aggregation (Plug Formation)
Reactome:R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
Reactome:R-HSA-372790 Signaling by GPCR
Reactome:R-HSA-159740 Gamma-carboxylation of protein precursors
Reactome:R-MMU-202733 Cell surface interactions at the vascular wall
Reactome:R-MMU-373076 Class A/1 (Rhodopsin-like receptors)
Reactome:R-MMU-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Reactome:R-RNO-392499 Metabolism of proteins
Reactome:R-RNO-159740 Gamma-carboxylation of protein precursors
Reactome:R-RNO-375276 Peptide ligand-binding receptors
Reactome:R-RNO-140877 Formation of Fibrin Clot (Clotting Cascade)
Reactome:R-HSA-109582 Hemostasis
Reactome:R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
Reactome:R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade)
Reactome:R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
Reactome:R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
Reactome:R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
Reactome:R-MMU-140875 Common Pathway of Fibrin Clot Formation
Reactome:R-MMU-372790 Signaling by GPCR
Reactome:R-MMU-392499 Metabolism of proteins
Reactome:R-MMU-597592 Post-translational protein modification
Reactome:R-MMU-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Reactome:R-RNO-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
Reactome:R-RNO-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
Reactome:R-RNO-500792 GPCR ligand binding
Reactome:R-RNO-140837 Intrinsic Pathway of Fibrin Clot Formation
Reactome:R-HSA-202733 Cell surface interactions at the vascular wall
Reactome:R-HSA-162582 Signaling Pathways
Reactome:R-HSA-375276 Peptide ligand-binding receptors
Reactome:R-HSA-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Reactome:R-HSA-5663205 Infectious disease
Reactome:R-MMU-109582 Hemostasis
Reactome:R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)
Reactome:R-MMU-140877 Formation of Fibrin Clot (Clotting Cascade)
Reactome:R-MMU-500792 GPCR ligand binding
Reactome:R-MMU-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
Reactome:R-MMU-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
Reactome:R-RNO-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Reactome:R-RNO-373076 Class A/1 (Rhodopsin-like receptors)
Reactome:R-RNO-76002 Platelet activation, signaling and aggregation
Reactome:R-RNO-140875 Common Pathway of Fibrin Clot Formation
WikiPathways:WP4927 COVID-19, thrombosis and anticoagulation
WikiPathways:WP5186 Vitamin K metabolism and activation of dependent proteins
PathBank:SMP0119394 Coagulation
PathBank:SMP0000274 Heparin Action Pathway
PathBank:SMP0000278 Lepirudin Action Pathway
PathBank:SMP0000282 Streptokinase Action Pathway
PathBank:SMP0000286 Aminocaproic Acid Action Pathway
PathBank:SMP0000269 Acenocoumarol Action Pathway
PathBank:SMP0119377 Coagulation
PathBank:SMP0000273 Fondaparinux Action Pathway
PathBank:SMP0000277 Bivalirudin Action Pathway
PathBank:SMP0000281 Anistreplase Action Pathway
PathBank:SMP0000285 Reteplase Action Pathway
PathBank:SMP0000268 Warfarin Action Pathway
PathBank:SMP0000656 Dicoumarol Action Pathway
PathBank:SMP0087321 Vitamin K Metabolism
PathBank:SMP0000275 Ardeparin Action Pathway
PathBank:SMP0000279 Ximelagatran Action Pathway
PathBank:SMP0000283 Tenecteplase Action Pathway
PathBank:SMP0000287 Tranexamic Acid Action Pathway
PathBank:SMP0000270 Dicumarol Action Pathway
PathBank:SMP0000586 Coagulation
PathBank:SMP0119368 Coagulation
PathBank:SMP0000272 Enoxaparin Action Pathway
PathBank:SMP0000276 Argatroban Action Pathway
PathBank:SMP0000280 Alteplase Action Pathway
PathBank:SMP0000284 Urokinase Action Pathway
PathBank:SMP0000288 Aprotinin Action Pathway
PathBank:SMP0000271 Phenprocoumon Action Pathway
PathBank:SMP0000655 Phenindione Action Pathway