数据之源，洞见之始

enzyme	lambda	metabolic reaction	experiment
uniprot:P23946 [chymase(Enzyme) wildtype] H2O + Angiotensin_I -> His_Leu + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] Angiotensin_I + H2O -> His_Leu + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [Heparin] Angiotensin_I + H2O -> Angiotensin_II + His_Leu	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 1.7 M KCl, 0.01% Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [Peptide] Angiotensin_I + H2O -> His_Leu + Angiotensin_II	(( (( (E * kcat) ) * S) ) / (( (Km * (1 + (I / Ki))) ) + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [Peptide] H2O + Angiotensin_I -> Angiotensin_II + His_Leu	(( (( (E * kcat) ) * S) ) / (( (Km * (1 + (I / Ki))) ) + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [Peptide] Angiotensin_I + H2O -> Angiotensin_II + His_Leu	(( (( (E * kcat) ) * S) ) / (( (Km * (1 + (I / Ki))) ) + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] H2O + Angiotensin_I -> Ala_Leu + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] Angiotensin_I + H2O -> Ile_Leu + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] H2O + Angiotensin_I -> Arg_Leu + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] Angiotensin_I + H2O -> Angiotensin_II + His_Leu	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] Angiotensin_I + H2O -> His_Leu + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] H2O + Angiotensin_I -> Phe_Leu + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [Peptide] H2O + Angiotensin_I -> His_Leu + Angiotensin_II	(( (( (E * kcat) ) * S) ) / (( (Km * (1 + (I / Ki))) ) + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [Peptide] H2O + Angiotensin_I -> His_Leu + Angiotensin_II	(( (( (E * kcat) ) * S) ) / (( (Km * (1 + (I / Ki))) ) + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [Peptide] H2O + Angiotensin_I -> His_Leu + Angiotensin_II	(( (( (E * kcat) ) * S) ) / (( (Km * (1 + (I / Ki))) ) + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] H2O + Angiotensin_I -> Angiotensin_II + Ile_Leu	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] Angiotensin_I + H2O -> His_Leu + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] H2O + Angiotensin_I -> Angiotensin_II + His_Leu	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] H2O + Angiotensin_I -> His_Leu + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] Angiotensin_I + H2O -> Angiotensin_II + His_Leu	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] H2O + Neurotensin -> Peptide + Ile_Leu	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] Angiotensin_I + H2O -> His_Ala + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] Angiotensin_I + H2O -> His_Val + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] H2O + Angiotensin_I -> His_Phe + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] H2O + Angiotensin_I -> His_Arg + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] H2O + Angiotensin_I -> Angiotensin_II + His_Asp	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] H2O + Angiotensin_I -> His_Pro + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] H2O + Angiotensin_I -> Angiotensin_II + His_Leu	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] H2O + Angiotensin_I -> His_Leu + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] H2O + Angiotensin_I -> His_Leu + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [Heparin] Angiotensin_I + H2O -> His_Leu + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.3 M KCl, 0.01% Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [Heparin] Angiotensin_I + H2O -> Angiotensin_II + His_Leu	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 1.0 M KCl, 0.01% Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] Angiotensin_I + H2O -> His_Leu + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.3 M KCl, 0.01% Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) mutant E2K] Angiotensin_I + H2O -> His_Leu + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.3 M KCl, 0.01% Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) mutant E2A] H2O + Angiotensin_I -> His_Leu + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.3 M KCl, 0.01% Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] H2O + Angiotensin_I -> L_Histidine + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [Peptide] H2O + Angiotensin_I -> His_Leu + Angiotensin_II	(( (( (E * kcat) ) * S) ) / (( (Km * (1 + (I / Ki))) ) + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [Peptide] H2O + Angiotensin_I -> His_Leu + Angiotensin_II	(( (( (E * kcat) ) * S) ) / (( (Km * (1 + (I / Ki))) ) + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [Peptide] H2O + Angiotensin_I -> Angiotensin_II + His_Leu	(( (( (E * kcat) ) * S) ) / (( (Km * (1 + (I / Ki))) ) + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] H2O + Angiotensin_I -> His_Leu + Angiotensin_II	(( (( (E * kcat) ) * S) ) / (( (Km * (1 + (I / Ki))) ) + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] H2O + Angiotensin_I -> His_Leu_Val + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] Angiotensin_I + H2O -> Angiotensin_II + His_Leu_Val_IIe_His_Asn	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] Angiotensin_I + H2O -> His_Leu_Val_IIe_His + Angiotensin_II	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37
uniprot:P23946 [chymase(Enzyme) wildtype] H2O + Angiotensin_I -> Angiotensin_II + His_Leu_Val_IIe	(( (( (kcat * E) ) * S) ) / (Km + S))		buffer: 20 mM Tris-HCl, 0.5 M KCl, 0.01 % Triton-X-100 PH: 8 Temperature: 37

Pathways

pathway id	name
Reactome:R-HSA-392499	Metabolism of proteins
Reactome:R-MMU-2980736	Peptide hormone metabolism
Reactome:R-CFA-2980736	Peptide hormone metabolism
Reactome:R-HSA-2980736	Peptide hormone metabolism
Reactome:R-MMU-2022377	Metabolism of Angiotensinogen to Angiotensins
Reactome:R-RNO-392499	Metabolism of proteins
Reactome:R-RNO-2980736	Peptide hormone metabolism
Reactome:R-CFA-392499	Metabolism of proteins
Reactome:R-MMU-392499	Metabolism of proteins
Reactome:R-CFA-2022377	Metabolism of Angiotensinogen to Angiotensins
Reactome:R-HSA-2022377	Metabolism of Angiotensinogen to Angiotensins
Reactome:R-RNO-2022377	Metabolism of Angiotensinogen to Angiotensins
WikiPathways:WP2729	Metabolism of Angiotensinogen to Angiotensins
WikiPathways:WP4818	Conversion of angiotensinogen to angiotensin II