EC: 3.1.8.1

aryldialkylphosphatase (aryltriphosphate dialkylphosphohydrolase)

enzyme lambda metabolic reaction experiment
uniprot:P27169 [Ca2+]

H2O + Paraoxon -> Diethylphosphoric_acid + p_Nitrophenol		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM Tris
PH: 8
Temperature: 36
uniprot:P27169 [Ca2+]

Paraoxon + H2O -> Diethylphosphoric_acid + p_Nitrophenol		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM Tris
PH: 8
Temperature: 36
uniprot:P27169 [Ca2+]

H2O + Paraoxon -> Diethylphosphoric_acid + p_Nitrophenol		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM Tris
PH: 8
Temperature: 36
uniprot:P27169 [Ca2+]

Paraoxon + H2O -> p_Nitrophenol + Diethylphosphoric_acid		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM Tris
PH: 8
Temperature: 36
uniprot:P0A434 [Co2+]

H2O + Paraoxon -> p_Nitrophenol + Diethylphosphoric_acid		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

Paraoxon + H2O -> Diethylphosphoric_acid + p_Nitrophenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Paraoxon -> Diethylphosphoric_acid + p_Nitrophenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Paraoxon -> p_Nitrophenol + Diethylphosphoric_acid		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Paraoxon -> Diethylphosphoric_acid + p_Nitrophenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Paraoxon -> p_Nitrophenol + Diethylphosphoric_acid		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Paraoxon -> p_Nitrophenol + Diethylphosphoric_acid		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

Paraoxon + H2O -> Diethylphosphoric_acid + p_Nitrophenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

Paraoxon + H2O -> Diethylphosphoric_acid + p_Nitrophenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [aryldialkylphosphatase(Enzyme) wildtype]

H2O + Paraoxon -> p_Nitrophenol + Diethylphosphoric_acid		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [aryldialkylphosphatase(Enzyme) mutant F132H]

Paraoxon + H2O -> Diethylphosphoric_acid + p_Nitrophenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [aryldialkylphosphatase(Enzyme) mutant F132Y]

Paraoxon + H2O -> Diethylphosphoric_acid + p_Nitrophenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [aryldialkylphosphatase(Enzyme) mutant F306K]

Paraoxon + H2O -> Diethylphosphoric_acid + p_Nitrophenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [aryldialkylphosphatase(Enzyme) mutant F306H]

H2O + Paraoxon -> p_Nitrophenol + Diethylphosphoric_acid		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [aryldialkylphosphatase(Enzyme) mutant F306Y]

Paraoxon + H2O -> Diethylphosphoric_acid + p_Nitrophenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Cd2+]

H2O + Paraoxon -> Diethylphosphoric_acid + p_Nitrophenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Cd2+]

Paraoxon + H2O -> p_Nitrophenol + Diethylphosphoric_acid		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Cd2+]

H2O + Paraoxon -> Diethylphosphoric_acid + p_Nitrophenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Aryl_dialkyl_phosphate -> Phenol + Dialkyl_phosphate		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Aryl_dialkyl_phosphate -> Phenol + Dialkyl_phosphate		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

Aryl_dialkyl_phosphate + H2O -> Dialkyl_phosphate + Phenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

Aryl_dialkyl_phosphate + H2O -> Dialkyl_phosphate + Phenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Aryl_dialkyl_phosphate -> Dialkyl_phosphate + Phenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Aryl_dialkyl_phosphate -> Dialkyl_phosphate + Phenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Aryl_dialkyl_phosphate -> Dialkyl_phosphate + Phenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

Acephate + H2O -> O,S_Dimethyl_phosphorothioate + Acetamide		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

Acephate + H2O -> O,S_Dimethyl_phosphorothioate + Acetamide		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Diisopropyl_fluorophosphate -> Diisopropyl_phosphate + F_		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Diisopropyl_fluorophosphate -> Diisopropyl_phosphate + F_		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

Diisopropyl_fluorophosphate + H2O -> Diisopropyl_phosphate + F_		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

Diisopropyl_fluorophosphate + H2O -> Diisopropyl_phosphate + F_		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

Diisopropyl_fluorophosphate + H2O -> Diisopropyl_phosphate + F_		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

Diisopropyl_fluorophosphate + H2O -> Diisopropyl_phosphate + F_		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

Diisopropyl_fluorophosphate + H2O -> F_ + Diisopropyl_phosphate		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Diisopropyl_fluorophosphate -> F_ + Diisopropyl_phosphate		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Diisopropyl_fluorophosphate -> Diisopropyl_phosphate + F_		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Paraoxon -> p_Nitrophenol + Diethylphosphoric_acid		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

Paraoxon + H2O -> p_Nitrophenol + Diethylphosphoric_acid		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Cd2+]

H2O + Paraoxon -> Diethylphosphoric_acid + p_Nitrophenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Cd2+]

Paraoxon + H2O -> Diethylphosphoric_acid + p_Nitrophenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Cd2+]

Paraoxon + H2O -> Diethylphosphoric_acid + p_Nitrophenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Cd2+]

H2O + Paraoxon -> p_Nitrophenol + Diethylphosphoric_acid		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Cd2+]

Paraoxon + H2O -> p_Nitrophenol + Diethylphosphoric_acid		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Cd2+]

Paraoxon + H2O -> p_Nitrophenol + Diethylphosphoric_acid		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Cd2+]

H2O + Paraoxon -> p_Nitrophenol + Diethylphosphoric_acid		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Cd2+]

H2O + Paraoxon -> Diethylphosphoric_acid + p_Nitrophenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Cd2+]

H2O + Paraoxon -> Diethylphosphoric_acid + p_Nitrophenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [aryldialkylphosphatase(Enzyme) mutant F132Y/F306H]

H2O + Paraoxon -> Diethylphosphoric_acid + p_Nitrophenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [aryldialkylphosphatase(Enzyme) mutant F132Y/F306Y]

H2O + Paraoxon -> p_Nitrophenol + Diethylphosphoric_acid		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [aryldialkylphosphatase(Enzyme) mutant F132H/F306Y]

Paraoxon + H2O -> Diethylphosphoric_acid + p_Nitrophenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [aryldialkylphosphatase(Enzyme) mutant F306E]

Paraoxon + H2O -> p_Nitrophenol + Diethylphosphoric_acid		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [aryldialkylphosphatase(Enzyme) mutant F132H/F306H]

H2O + Paraoxon -> p_Nitrophenol + Diethylphosphoric_acid		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Aryl_dialkyl_phosphate -> Dialkyl_phosphate + Phenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Aryl_dialkyl_phosphate -> Phenol + Dialkyl_phosphate		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Aryl_dialkyl_phosphate -> Dialkyl_phosphate + Phenol		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

Aryl_dialkyl_phosphate + H2O -> Phenol + Dialkyl_phosphate		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Acephate -> O,S_Dimethyl_phosphorothioate + Acetamide		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

Acephate + H2O -> O,S_Dimethyl_phosphorothioate + Acetamide		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Acephate -> O,S_Dimethyl_phosphorothioate + Acetamide		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Acephate -> Acetamide + O,S_Dimethyl_phosphorothioate		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

Acephate + H2O -> Acetamide + O,S_Dimethyl_phosphorothioate		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

Acephate + H2O -> Acetamide + O,S_Dimethyl_phosphorothioate		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Acephate -> O,S_Dimethyl_phosphorothioate + Acetamide		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

Acephate + H2O -> Acetamide + O,S_Dimethyl_phosphorothioate		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Acephate -> Acetamide + O,S_Dimethyl_phosphorothioate		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Diisopropyl_fluorophosphate -> Diisopropyl_phosphate + F_		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25
uniprot:P0A434 [Co2+]

H2O + Diisopropyl_fluorophosphate -> Diisopropyl_phosphate + F_		 (( (V * A) ) / (Ka + A)) buffer: 100 mM CHES
PH: 9
Temperature: 25

Pathways

pathway id name
BioCyc:META_PARATHION-DEGRADATION-PWY parathion degradation
BioCyc:MOUSE_PWY-5489 methyl parathion degradation
BioCyc:MOUSE_PWY-5490 paraoxon degradation
BioCyc:META_PWY-5490 paraoxon degradation
BioCyc:MOUSE_PARATHION-DEGRADATION-PWY parathion degradation
Reactome:R-RNO-9748784 Drug ADME
Reactome:R-HSA-9754706 Atorvastatin ADME
Reactome:R-RNO-9754706 Atorvastatin ADME
Reactome:R-MMU-9748784 Drug ADME
Reactome:R-HSA-9748784 Drug ADME
Reactome:R-MMU-9754706 Atorvastatin ADME
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-556833 Metabolism of lipids
Reactome:R-RNO-8978868 Fatty acid metabolism
Reactome:R-HSA-556833 Metabolism of lipids
Reactome:R-HSA-8978868 Fatty acid metabolism
Reactome:R-MMU-8978868 Fatty acid metabolism
Reactome:R-RNO-2142753 Arachidonate metabolism
Reactome:R-HSA-2142688 Synthesis of 5-eicosatetraenoic acids
Reactome:R-MMU-2142688 Synthesis of 5-eicosatetraenoic acids
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-556833 Metabolism of lipids
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-2142753 Arachidonate metabolism
Reactome:R-MMU-2142753 Arachidonate metabolism
Reactome:R-RNO-2142688 Synthesis of 5-eicosatetraenoic acids
WikiPathways:WP4157 GABA metabolism (aka GHB)
PathBank:SMP0000610 Clopidogrel Metabolism Pathway
PathBank:SMP0000260 Clopidogrel Action Pathway