EC: 3.1.4.1

phosphodiesterase I (oligonucleotide 5'-nucleotidohydrolase)

enzyme lambda metabolic reaction experiment
uniprot:Q13822 [Enzyme wildtype NPP2]

H2O + P1,P3_Bis(5'_adenosyl)_triphosphate -> AMP + ADP
(( (Vmax * S) ) / (Km + S)) buffer: 25 mM Tris/ 25 mM glycine, 140 mM NaCl, 5 mM KCl, 500 µg/ml bovine serum albumin, 1 mM CaCl2, 1 mM MgCl2
PH: 9
Temperature: 37
uniprot:P22413 [Enzyme wildtype NPP1]

H2O + P1,P3_Bis(5'_adenosyl)_triphosphate -> AMP + ADP
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Hepes, 140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 1 mM CaCl2
PH: 8.5
Temperature: 37
uniprot:P97675 [Enzyme wildtype NPP3]

H2O + P1,P3_Bis(5'_adenosyl)_triphosphate -> ADP + AMP
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Hepes, 140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 1 mM CaCl2
PH: 8.5
Temperature: 37
uniprot:Q58346 [Ni2+]

Bis_4_nitrophenyl_phosphate + H2O -> 4_Nitrophenyl_phosphate + p_Nitrophenol
(( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM Diethanolamine, 40 mM NaCl
PH: 9.8
Temperature: 70
uniprot:Q58346 [Ni2+]

H2O + Bis_4_nitrophenyl_phosphate -> p_Nitrophenol + 4_Nitrophenyl_phosphate
(( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM Diethanolamine, 40 mM NaCl
PH: 9.8
Temperature: 70
uniprot:Q58346 [Mn2+]

4_Nitrophenyl_phosphocholine + H2O -> Choline + 4_Nitrophenyl_phosphate
(( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM Diethanolamine, 40 mM NaCl
PH: 9.8
Temperature: 70
uniprot:Q58346 [Ni2+]

p_Nitrophenylthymidine_phosphate + H2O -> dTMP + p_Nitrophenol
(( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM Diethanolamine, 40 mM NaCl
PH: 9.8
Temperature: 70
uniprot:Q58346 [Ni2+]

H2O + 4_Nitrophenyl_phosphocholine -> 4_Nitrophenyl_phosphate + Choline
(( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM Diethanolamine, 40 mM NaCl
PH: 9.8
Temperature: 70
uniprot:Q58346 [Ni2+]

H2O + Bis_4_nitrophenyl_phosphate -> 4_Nitrophenyl_phosphate + p_Nitrophenol
(( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM Diethanolamine, 40 mM NaCl
PH: 9.8
Temperature: 70
- [phosphodiesterase I(Enzyme) wildtype]

Adenylyl_3',5'_guanosine + H2O -> GMP + Adenosine
(( (Vmax * A) ) / (Km + A)) buffer: 50 mM Tris-HCl, 1 mM MnCl2, 0.5 mM EDTA, 7.5 mM dithiothreitol
PH: 7.9
Temperature: 37
- [phosphodiesterase I(Enzyme) wildtype]

H2O + p_Nitrophenylthymidine_phosphate -> p_Nitrophenol + dTMP
(( (Vmax * A) ) / (Km + A)) buffer: 50 mM Tris-HCl, 1 mM MnCl2, 0.5 mM EDTA, 7.5 mM dithiothreitol
PH: 7.9
Temperature: 37
- [phosphodiesterase I(Enzyme) wildtype]

H2O + Adenylyl_3',5'_adenosine -> Adenosine + AMP
(( (Vmax * A) ) / (Km + A)) buffer: 50 mM Tris-HCl, 1 mM MnCl2, 0.5 mM EDTA, 7.5 mM dithiothreitol
PH: 7.9
Temperature: 37
- [phosphodiesterase I(Enzyme) wildtype]

H2O + Cytidylyl_3',5'_uracil -> Cytidine + UMP
(( (Vmax * A) ) / (Km + A)) buffer: 50 mM Tris-HCl, 1 mM MnCl2, 0.5 mM EDTA, 7.5 mM dithiothreitol
PH: 7.9
Temperature: 37
- [phosphodiesterase I(Enzyme) wildtype]

Adenylyl_3',5'_cytidine + H2O -> Adenosine + CMP
(( (Vmax * A) ) / (Km + A)) buffer: 50 mM Tris-HCl, 1 mM MnCl2, 0.5 mM EDTA, 7.5 mM dithiothreitol
PH: 7.9
Temperature: 37
- [phosphodiesterase I(Enzyme) wildtype]

6 H2O + U(pU)6 -> Uridine + 6 UMP
(( (Vmax * A) ) / (Km + A)) buffer: 50 mM Tris-HCl, 1 mM MnCl2, 0.5 mM EDTA, 7.5 mM dithiothreitol
PH: 7.9
Temperature: 37
- [phosphodiesterase I(Enzyme) wildtype]

ATP + H2O -> AMP + Diphosphate
(( (V * S) ) / (Km + S)) buffer: 100 mM glycine-NaOH, 5 mM MgCl2, 100 µM ZnCl2
PH: 9.6
Temperature: 37
- [phosphodiesterase I(Enzyme) wildtype]

ATP + H2O -> Diphosphate + AMP
(( (V * S) ) / (Km + S)) buffer: 100 mM glycine-NaOH, 5 mM MgCl2, 100 µM ZnCl2
PH: 9.6
Temperature: 37

Pathways

pathway id name
BioCyc:MOUSE_PWY3DJ-81 riboflavin, FMN and FAD transformations
Reactome:R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-HSA-199220 Vitamin B5 (pantothenate) metabolism
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-RNO-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-HSA-196854 Metabolism of vitamins and cofactors
Reactome:R-HSA-196843 Vitamin B2 (riboflavin) metabolism
Reactome:R-MMU-6783310 Fanconi Anemia Pathway
Reactome:R-MMU-196854 Metabolism of vitamins and cofactors
Reactome:R-MMU-196843 Vitamin B2 (riboflavin) metabolism
Reactome:R-RNO-196854 Metabolism of vitamins and cofactors
Reactome:R-RNO-196843 Vitamin B2 (riboflavin) metabolism
Reactome:R-DRE-73894 DNA Repair
Reactome:R-HSA-6783310 Fanconi Anemia Pathway
Reactome:R-MMU-73894 DNA Repair
Reactome:R-RNO-1430728 Metabolism
Reactome:R-DRE-6783310 Fanconi Anemia Pathway
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-73894 DNA Repair
PathBank:SMP0000070 Riboflavin Metabolism
PathBank:SMP0000027 Pantothenate and CoA Biosynthesis
PathBank:SMP0000048 Nicotinate and Nicotinamide Metabolism