EC: 3.1.3.91

7-methylguanosine nucleotidase (N7-methyl-GMP phosphohydrolase)

enzyme lambda metabolic reaction experiment
uniprot:Q969T7 [null(Enzyme) wildtype cNIII-like]

H2O + UMP -> Uridine + Phosphate		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 20 mM HEPES-KOH, 5 mM MgCl2, 50 mM KCl, 50 µM Potassium phosphate
PH: 7.5
Temperature: 37
uniprot:Q969T7 [null(Enzyme) wildtype cNIII-like]

CMP + H2O -> Phosphate + Cytidine		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 20 mM HEPES-KOH, 5 mM MgCl2, 50 mM KCl, 50 µM Potassium phosphate
PH: 7.5
Temperature: 37
uniprot:Q9W197 [null(Enzyme) wildtype CG3362]

7_Methylguanosine_5'_phosphate + H2O -> Phosphate + 7_Methylguanosine		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 20 mM HEPES-KOH, 5 mM MgCl2, 50 mM KCl, 50 µM Potassium phosphate
PH: 7.5
Temperature: 25
uniprot:Q969T7 [null(Enzyme) wildtype cNIII-like]

H2O + 7_Methylguanosine_5'_phosphate -> Phosphate + 7_Methylguanosine		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 20 mM HEPES-KOH, 5 mM MgCl2, 50 mM KCl, 50 µM Potassium phosphate
PH: 7.5
Temperature: 37
uniprot:Q9W197 [null(Enzyme) wildtype CG3362]

H2O + UMP -> Phosphate + Uridine		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 20 mM HEPES-KOH, 5 mM MgCl2, 50 mM KCl, 50 µM Potassium phosphate
PH: 7.5
Temperature: 25
uniprot:Q9W197 [null(Enzyme) wildtype CG3362]

CMP + H2O -> Cytidine + Phosphate		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 20 mM HEPES-KOH, 5 mM MgCl2, 50 mM KCl, 50 µM Potassium phosphate
PH: 7.5
Temperature: 25

Pathways

pathway id name
BioCyc:HUMAN_PWY-5695 urate biosynthesis/inosine 5'-phosphate degradation
BioCyc:META_SALVADEHYPOX-PWY adenosine nucleotides degradation II
BioCyc:META_PWY-5695 inosine 5'-phosphate degradation
BioCyc:MOUSE_URSIN-PWY ureide biosynthesis
BioCyc:MOUSE_PWY-6353 purine nucleotides degradation II (aerobic)
BioCyc:HUMAN_SALVADEHYPOX-PWY adenosine nucleotides degradation
BioCyc:MOUSE_PWY-5695 urate biosynthesis/inosine 5'-phosphate degradation
BioCyc:HUMAN_PWY-6353 purine nucleotides degradation
BioCyc:META_PWY-6353 purine nucleotides degradation II (aerobic)
Reactome:R-HSA-9660826 Purinergic signaling in leishmaniasis infection
Reactome:R-HSA-9664424 Cell recruitment (pro-inflammatory response)
Reactome:R-HSA-9658195 Leishmania infection
Reactome:R-HSA-9824443 Parasitic Infection Pathways
Reactome:R-DME-8953854 Metabolism of RNA
Reactome:R-DME-73621 Pyrimidine catabolism
Reactome:R-GGA-15869 Nucleotide metabolism
Reactome:R-GGA-8956319 Nucleotide catabolism
Reactome:R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-HSA-1643685 Disease
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-MMU-8953854 Metabolism of RNA
Reactome:R-MMU-429914 Deadenylation-dependent mRNA decay
Reactome:R-RNO-429958 mRNA decay by 3' to 5' exoribonuclease
Reactome:R-RNO-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-DME-429914 Deadenylation-dependent mRNA decay
Reactome:R-DME-1430728 Metabolism
Reactome:R-GGA-73621 Pyrimidine catabolism
Reactome:R-HSA-74259 Purine catabolism
Reactome:R-HSA-196854 Metabolism of vitamins and cofactors
Reactome:R-HSA-429914 Deadenylation-dependent mRNA decay
Reactome:R-MMU-74259 Purine catabolism
Reactome:R-MMU-196854 Metabolism of vitamins and cofactors
Reactome:R-RNO-74259 Purine catabolism
Reactome:R-RNO-196854 Metabolism of vitamins and cofactors
Reactome:R-DME-429958 mRNA decay by 3' to 5' exoribonuclease
Reactome:R-DME-15869 Nucleotide metabolism
Reactome:R-DME-8956319 Nucleotide catabolism
Reactome:R-GGA-1430728 Metabolism
Reactome:R-HSA-73621 Pyrimidine catabolism
Reactome:R-HSA-196807 Nicotinate metabolism
Reactome:R-HSA-8953854 Metabolism of RNA
Reactome:R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease
Reactome:R-MMU-73621 Pyrimidine catabolism
Reactome:R-MMU-196807 Nicotinate metabolism
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-73621 Pyrimidine catabolism
Reactome:R-RNO-196807 Nicotinate metabolism
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-15869 Nucleotide metabolism
Reactome:R-HSA-8956319 Nucleotide catabolism
Reactome:R-HSA-5663205 Infectious disease
Reactome:R-MMU-15869 Nucleotide metabolism
Reactome:R-MMU-8956319 Nucleotide catabolism
Reactome:R-MMU-429958 mRNA decay by 3' to 5' exoribonuclease
Reactome:R-RNO-8953854 Metabolism of RNA
Reactome:R-RNO-429914 Deadenylation-dependent mRNA decay
Reactome:R-RNO-15869 Nucleotide metabolism
Reactome:R-RNO-8956319 Nucleotide catabolism
WikiPathways:WP4584 Biomarkers for pyrimidine metabolism disorders
WikiPathways:WP5078 T cell modulation in pancreatic cancer
WikiPathways:WP4225 Pyrimidine metabolism and related diseases