EC: 2.1.1.5

betaine-homocysteine S-methyltransferase (trimethylammonioacetate:L-homocysteine S-methyltransferase)

enzyme lambda metabolic reaction experiment
uniprot:Q93088 [Isovaleric acid]

L_Homocysteine + Betaine -> N,N_Dimethylglycine + L_Methionine		 (( (Vmax * B) ) / (( (Km * (1 + (I / Ki))) ) + B)) buffer: 100 mM Potassium phosphate
PH: 7.4
Temperature: 37
uniprot:Q93088 [3,3-Dimethylbutanoate]

L_Homocysteine + Betaine -> L_Methionine + N,N_Dimethylglycine		 (( (Vmax * B) ) / (( (Km * (1 + (I / Ki))) ) + B)) buffer: 100 mM Potassium phosphate
PH: 7.4
Temperature: 37
uniprot:Q93088 [betaine---homocysteine S-methyltransferase(Enzyme) wildtype]

L_Homocysteine + Betaine -> N,N_Dimethylglycine + L_Methionine		 (( (Vmax * A) ) / (Km + A)) buffer: 100 mM Potassium phosphate
PH: 7.4
Temperature: 37
uniprot:Q93088 [betaine---homocysteine S-methyltransferase(Enzyme) wildtype]

L_Homocysteine + Betaine -> N,N_Dimethylglycine + L_Methionine		 (( (Vmax * B) ) / (Km + B)) buffer: 100 mM Potassium phosphate
PH: 7.4
Temperature: 37

Pathways

pathway id name
BioCyc:HUMAN_PWY66-414 superpathway of choline degradation to L-serine
BioCyc:HUMAN_PWY-5328 superpathway of methionine degradation
BioCyc:META_PWY-5328 superpathway of L-methionine salvage and degradation
BioCyc:MOUSE_PWY-5328 superpathway of methionine degradation
BioCyc:MOUSE_ADENOSYLHOMOCYSCAT-PWY methionine salvage II (mammalia)
BioCyc:HUMAN_PWY-3661-1 glycine betaine degradation II (mammalian)
BioCyc:META_ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine
BioCyc:HUMAN_ADENOSYLHOMOCYSCAT-PWY methionine salvage
BioCyc:META_PWY-3661-1 glycine betaine degradation II (mammalian)
BioCyc:META_PWY-3661 glycine betaine degradation I
BioCyc:MOUSE_PWY-3661 glycine betaine degradation
Reactome:R-DRE-71291 Amino acid and derivative metabolism
Reactome:R-HSA-6798163 Choline catabolism
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-6798163 Choline catabolism
Reactome:R-RNO-6798163 Choline catabolism
Reactome:R-DRE-1430728 Metabolism
Reactome:R-DRE-1614635 Sulfur amino acid metabolism
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-71291 Amino acid and derivative metabolism
Reactome:R-DRE-6798163 Choline catabolism
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-1614635 Sulfur amino acid metabolism
Reactome:R-MMU-1614635 Sulfur amino acid metabolism
Reactome:R-RNO-1614635 Sulfur amino acid metabolism
WikiPathways:WP4288 MTHFR deficiency
WikiPathways:WP4504 Cysteine and methionine catabolism
PathBank:SMP0000177 Cystathionine beta-Synthase Deficiency
PathBank:SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
PathBank:SMP0002313 Sarcosine Oncometabolite Pathway
PathBank:SMP0000033 Methionine Metabolism
PathBank:SMP0000222 Glycine N-Methyltransferase Deficiency
PathBank:SMP0000123 Betaine Metabolism
PathBank:SMP0000341 Hypermethioninemia
PathBank:SMP0000221 Methionine Adenosyltransferase Deficiency
PathBank:SMP0000214 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
PathBank:SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type