EC: 2.1.1.13

methionine synthase (5-methyltetrahydrofolate:L-homocysteine S-methyltransferase)

enzyme lambda metabolic reaction experiment
uniprot:Q9MYZ4 [methionine synthase(Enzyme) wildtype]

L_Homocysteine + 5_Methyltetrahydrofolate -> 5,6,7,8_Tetrahydrofolate + L_Methionine		 (( (E * kcat) ) / (( (( (1 + (Ka / A)) ) + (Kb / B)) ) + (( (Kia * Kb) ) / (A * B)))) buffer: 100 mM potassium phosphate, 19 µM S-adenosylmethionine (iodide salt), 50 µM aquocobalamin, 25 mM dithiothreitol
PH: 7.2
Temperature: 37
uniprot:Q9MYZ4 [methionine synthase(Enzyme) wildtype]

5_Methyltetrahydrofolate + L_Homocysteine -> 5,6,7,8_Tetrahydrofolate + L_Methionine		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 100 mM potassium phosphate, 19 µM S-adenosylmethionine (iodide salt), 50 µM aquocobalamin, 25 mM dithiothreitol
PH: 7.2
Temperature: 37

Pathways

pathway id name
BioCyc:HUMAN_PWY-5328 superpathway of methionine degradation
BioCyc:META_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:META_PWY-2201 folate transformations I
BioCyc:META_PWY0-781 aspartate superpathway
BioCyc:META_PWY-5328 superpathway of L-methionine salvage and degradation
BioCyc:ECO_HOMOSER-METSYN-PWY L-methionine biosynthesis I
BioCyc:VCHO_PWY-3841 folate transformations II
BioCyc:VCHO_P4-PWY superpathway of L-lysine, L-threonine and L-methionine biosynthesis I
BioCyc:MTBH37RV_PWY-5345 superpathway of L-methionine biosynthesis (by sulfhydrylation)
BioCyc:ECOL316407_P4-PWY superpathway of lysine, threonine and methionine biosynthesis I
BioCyc:ECOL316407_METSYN-PWY homoserine and methionine biosynthesis
BioCyc:ECOL316407_PWY0-781 aspartate superpathway
BioCyc:ECO_P4-PWY superpathway of L-lysine, L-threonine and L-methionine biosynthesis I
BioCyc:VCHO_METSYN-PWY L-homoserine and L-methionine biosynthesis
BioCyc:VCHO_PWY-2201 folate transformations I
BioCyc:VCHO_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:MTBH37RV_HSERMETANA-PWY L-methionine biosynthesis III
BioCyc:MOUSE_PWY-5328 superpathway of methionine degradation
BioCyc:MOUSE_ADENOSYLHOMOCYSCAT-PWY methionine salvage II (mammalia)
BioCyc:MOUSE_PWY-2201 folate transformations I
BioCyc:ECOL316407_HOMOSER-METSYN-PWY methionine biosynthesis I
BioCyc:ECOL316407_MET-SAM-PWY superpathway of S-adenosyl-L-methionine biosynthesis
BioCyc:META_PWY-5347 superpathway of L-methionine biosynthesis (transsulfuration)
BioCyc:META_HOMOSER-METSYN-PWY L-methionine biosynthesis I
BioCyc:META_ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine
BioCyc:ECO_MET-SAM-PWY superpathway of S-adenosyl-L-methionine biosynthesis
BioCyc:ECO_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:VCHO_PWY-5347 superpathway of L-methionine biosynthesis (transsulfuration)
BioCyc:VCHO_HOMOSER-METSYN-PWY L-methionine biosynthesis I
BioCyc:VCHO_PWY0-781 aspartate superpathway
BioCyc:MTBH37RV_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:HUMAN_ADENOSYLHOMOCYSCAT-PWY methionine salvage
BioCyc:HUMAN_PWY-2201 folate transformations I
BioCyc:META_METSYN-PWY superpathway of L-homoserine and L-methionine biosynthesis
BioCyc:META_P4-PWY superpathway of L-lysine, L-threonine and L-methionine biosynthesis I
BioCyc:META_MET-SAM-PWY superpathway of S-adenosyl-L-methionine biosynthesis
BioCyc:ECO_PWY0-781 aspartate superpathway
BioCyc:ECO_METSYN-PWY superpathway of L-homoserine and L-methionine biosynthesis
BioCyc:MOUSE_PWY-3841 folate transformations II (plants)
BioCyc:ECOL316407_1CMET2-PWY formylTHF biosynthesis
WikiPathways:WP2472 Escherichia coli K-12 peripherome
PathBank:SMP0000834 Methionine Biosynthesis
PathBank:SMP0001750 One Carbon Pool by Folate
PathBank:SMP0002092 S-Adenosyl-L-Methionine Cycle
Reactome:R-CEL-9759218 Cobalamin (Cbl) metabolism
Reactome:R-HSA-9759218 Cobalamin (Cbl) metabolism
Reactome:R-DDI-9759218 Cobalamin (Cbl) metabolism
Reactome:R-MMU-9759218 Cobalamin (Cbl) metabolism
Reactome:R-RNO-9759218 Cobalamin (Cbl) metabolism
Reactome:R-CEL-1614635 Sulfur amino acid metabolism
Reactome:R-CEL-211859 Biological oxidations
Reactome:R-DDI-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-DDI-211859 Biological oxidations
Reactome:R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-HSA-211859 Biological oxidations
Reactome:R-HSA-156581 Methylation
Reactome:R-HSA-1643685 Disease
Reactome:R-HSA-3296469 Defects in cobalamin (B12) metabolism
Reactome:R-HSA-3359467 Defective MTRR causes HMAE
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-MMU-211859 Biological oxidations
Reactome:R-MMU-156581 Methylation
Reactome:R-RNO-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-CEL-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-DDI-196854 Metabolism of vitamins and cofactors
Reactome:R-DDI-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
Reactome:R-DDI-71291 Amino acid and derivative metabolism
Reactome:R-HSA-196854 Metabolism of vitamins and cofactors
Reactome:R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
Reactome:R-HSA-156580 Phase II - Conjugation of compounds
Reactome:R-HSA-3296482 Defects in vitamin and cofactor metabolism
Reactome:R-MMU-196854 Metabolism of vitamins and cofactors
Reactome:R-MMU-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
Reactome:R-MMU-156580 Phase II - Conjugation of compounds
Reactome:R-RNO-196854 Metabolism of vitamins and cofactors
Reactome:R-RNO-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
Reactome:R-RNO-211859 Biological oxidations
Reactome:R-RNO-156581 Methylation
Reactome:R-CEL-71291 Amino acid and derivative metabolism
Reactome:R-CEL-156580 Phase II - Conjugation of compounds
Reactome:R-CEL-156581 Methylation
Reactome:R-DDI-1614635 Sulfur amino acid metabolism
Reactome:R-DDI-156580 Phase II - Conjugation of compounds
Reactome:R-DDI-156581 Methylation
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-HSA-5668914 Diseases of metabolism
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-71291 Amino acid and derivative metabolism
Reactome:R-CEL-1430728 Metabolism
Reactome:R-CEL-196854 Metabolism of vitamins and cofactors
Reactome:R-CEL-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
Reactome:R-DDI-1430728 Metabolism
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-1614635 Sulfur amino acid metabolism
Reactome:R-MMU-1614635 Sulfur amino acid metabolism
Reactome:R-RNO-1614635 Sulfur amino acid metabolism
Reactome:R-RNO-156580 Phase II - Conjugation of compounds
WikiPathways:WP4292 Methionine metabolism leading to sulfur amino acids and related disorders
WikiPathways:WP4504 Cysteine and methionine catabolism
WikiPathways:WP4259 Disorders of folate metabolism and transport
WikiPathways:WP4271 Vitamin B12 disorders
PathBank:SMP0120718 Hypermethioninemia
PathBank:SMP0108776 Sarcosine Oncometabolite Pathway
PathBank:SMP0002313 Sarcosine Oncometabolite Pathway
PathBank:SMP0087342 Methionine Metabolism
PathBank:SMP0063600 Betaine Metabolism
PathBank:SMP0120853 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type
PathBank:SMP0120471 Cystathionine beta-Synthase Deficiency
PathBank:SMP0120487 Glycine N-Methyltransferase Deficiency
PathBank:SMP0120519 Methionine Adenosyltransferase Deficiency
PathBank:SMP0120527 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
PathBank:SMP0087249 Methionine Metabolism
PathBank:SMP0087285 Betaine Metabolism
PathBank:SMP0063637 Methionine Metabolism
PathBank:SMP0108762 Sarcosine Oncometabolite Pathway
PathBank:SMP0120634 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type
PathBank:SMP0000123 Betaine Metabolism
PathBank:SMP0120691 Cystathionine beta-Synthase Deficiency
PathBank:SMP0120707 Glycine N-Methyltransferase Deficiency
PathBank:SMP0120739 Methionine Adenosyltransferase Deficiency
PathBank:SMP0120747 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
PathBank:SMP0120498 Hypermethioninemia
PathBank:SMP0087182 Betaine Metabolism
PathBank:SMP0087483 Methionine Metabolism