EC: 1.8.4.14

L-methionine (R)-S-oxide reductase (L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming])

enzyme lambda metabolic reaction experiment
uniprot:P76270 [L-methionine (R)-S-oxide reductase(Enzyme) wildtype]

L_Methionine_(R)_S_oxide + Reduced_thioredoxin -> Oxidized_thioredoxin + L_Methionine + H2O		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 20 mM Hepes, 10 mM NaCl, 250 µM NADPH, 0.64 µM thioredoxin reductase
PH: 7.4
Temperature: 37
uniprot:P76270 [L-methionine (R)-S-oxide reductase(Enzyme) wildtype]

L_Methionine_(R)_S_oxide + Reduced_thioredoxin -> H2O + L_Methionine + Oxidized_thioredoxin		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 20 mM Hepes, 10 mM NaCl, 250 µM NADPH, 0.64 µM thioredoxin reductase
PH: 7.4
Temperature: 37
uniprot:P36088 [L-methionine (R)-S-oxide reductase(Enzyme) wildtype His-tagged]

Reduced_thioredoxin + L_Methionine_(R)_S_oxide -> Oxidized_thioredoxin + L_Methionine + H2O		 (( (Vmax * S) ) / (Km + S)) buffer: PBS, 50 mM DTT
PH: 7.4
Temperature: 37

Pathways

pathway id name
PathBank:SMP0120718 Hypermethioninemia
PathBank:SMP0000177 Cystathionine beta-Synthase Deficiency
PathBank:SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
PathBank:SMP0087342 Methionine Metabolism
PathBank:SMP0120853 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type
PathBank:SMP0120471 Cystathionine beta-Synthase Deficiency
PathBank:SMP0120487 Glycine N-Methyltransferase Deficiency
PathBank:SMP0120519 Methionine Adenosyltransferase Deficiency
PathBank:SMP0120527 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
PathBank:SMP0000033 Methionine Metabolism
PathBank:SMP0000222 Glycine N-Methyltransferase Deficiency
PathBank:SMP0063637 Methionine Metabolism
PathBank:SMP0120634 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type
PathBank:SMP0000341 Hypermethioninemia
PathBank:SMP0000221 Methionine Adenosyltransferase Deficiency
PathBank:SMP0120691 Cystathionine beta-Synthase Deficiency
PathBank:SMP0120707 Glycine N-Methyltransferase Deficiency
PathBank:SMP0120739 Methionine Adenosyltransferase Deficiency
PathBank:SMP0120747 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
PathBank:SMP0120498 Hypermethioninemia
PathBank:SMP0000214 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
PathBank:SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type