EC: 1.21.1.1

iodotyrosine deiodinase (NADP+:L-tyrosine oxidoreductase (iodinating))

enzyme lambda metabolic reaction experiment
uniprot:Q6PHW0 [iodotyrosine deiodinase(Enzyme) wildtype]

2 NADPH + 2 H+ + 3,5_Diiodo_L_tyrosine -> 2 I_ + 2 NADP+ + L_Tyrosine		 (( (Vmax * A) ) / (Km + A)) buffer: 100 mM potassium phosphate, 50 mM 2-mercaptoethanol, 200 mM KCl, 30 µM FAD, 1.5 mM methimazole
PH: 7.4
Temperature: 36
uniprot:Q6PHW0 [iodotyrosine deiodinase(Enzyme) wildtype]

H+ + 3_Iodo_L_tyrosine + NADPH -> NADP+ + L_Tyrosine + I_		 (( (Vmax * A) ) / (Km + A)) buffer: 100 mM potassium phosphate, 50 mM 2-mercaptoethanol, 200 mM KCl, 30 µM FAD, 1.5 mM methimazole
PH: 7.4
Temperature: 36

Pathways

pathway id name
Reactome:R-DRE-71291 Amino acid and derivative metabolism
Reactome:R-DRE-209968 Thyroxine biosynthesis
Reactome:R-DME-209776 Metabolism of amine-derived hormones
Reactome:R-MMU-1430728 Metabolism
Reactome:R-DME-1430728 Metabolism
Reactome:R-DME-71291 Amino acid and derivative metabolism
Reactome:R-HSA-209776 Metabolism of amine-derived hormones
Reactome:R-MMU-209776 Metabolism of amine-derived hormones
Reactome:R-RNO-209776 Metabolism of amine-derived hormones
Reactome:R-DRE-1430728 Metabolism
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-HSA-209968 Thyroxine biosynthesis
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-MMU-209968 Thyroxine biosynthesis
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-71291 Amino acid and derivative metabolism
Reactome:R-RNO-209968 Thyroxine biosynthesis
Reactome:R-DRE-209776 Metabolism of amine-derived hormones
Reactome:R-DME-209968 Thyroxine biosynthesis
Reactome:R-HSA-1430728 Metabolism